12 Games
| G | Date | Time | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 4, 2021 | 8:00 PM | Sat | South Alabama | Southern Mississippi | CUSA | W | 31 | 7 | 1 | 0 | W 1 | ||
| 2 | Sep 11, 2021 | 4:00 PM | Sat | South Alabama | @ | Bowling Green | MAC | W | 22 | 19 | 2 | 0 | W 2 | |
| 3 | Sep 18, 2021 | 8:00 PM | Sat | South Alabama | Alcorn State | Non-Major | W | 28 | 21 | 3 | 0 | W 3 | ||
| 4 | Oct 2, 2021 | 8:00 PM | Sat | South Alabama | Louisiana | Sun Belt | L | 18 | 20 | 3 | 1 | L 1 | ||
| 5 | Oct 9, 2021 | 7:00 PM | Sat | South Alabama | @ | Texas State | Sun Belt | L | 31 | 33 | 3 | 2 | L 2 | |
| 6 | Oct 14, 2021 | 7:30 PM | Thu | South Alabama | Georgia Southern | Sun Belt | W | 41 | 14 | 4 | 2 | W 1 | ||
| 7 | Oct 23, 2021 | 7:00 PM | Sat | South Alabama | @ | Louisiana-Monroe | Sun Belt | L | 31 | 41 | 4 | 3 | L 1 | |
| 8 | Oct 30, 2021 | 5:00 PM | Sat | South Alabama | Arkansas State | Sun Belt | W | 31 | 13 | 5 | 3 | W 1 | ||
| 9 | Nov 6, 2021 | 3:30 PM | Sat | South Alabama | @ | Troy | Sun Belt | L | 24 | 31 | 5 | 4 | L 1 | |
| 10 | Nov 13, 2021 | 2:30 PM | Sat | South Alabama | @ | Appalachian State | Sun Belt | L | 7 | 31 | 5 | 5 | L 2 | |
| 11 | Nov 20, 2021 | 7:30 PM | Sat | South Alabama | @ | Tennessee | SEC | L | 14 | 60 | 5 | 6 | L 3 | |
| 12 | Nov 26, 2021 | 3:30 PM | Fri | South Alabama | Coastal Carolina | Sun Belt | L | 21 | 27 | 5 | 7 | L 4 |
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