| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 36 | 1 | 2021-09-04 | Cincinnati | Miami (OH) | REG (Non-Conf) | W 49-14 | ||
| 2 | 37 | 2 | 2021-09-11 | Cincinnati | Murray St. | REG (Non-Conf) | W 42-7 | ||
| 3 | 38 | 6 | 2021-10-16 | Cincinnati | UCF | REG (Conf) | W 56-21 | ||
| 4 | 39 | 9 | 2021-11-06 | Cincinnati | Tulsa | REG (Conf) | W 28-20 | ||
| 5 | 40 | 10 | 2021-11-12 | Cincinnati | @ | South Florida | REG (Conf) | W 45-28 | |
| 6 | 41 | 11 | 2021-11-20 | Cincinnati | SMU | REG (Conf) | W 48-14 | ||
| 7 | 42 | 12 | 2021-11-26 | Cincinnati | @ | East Carolina | REG (Conf) | W 35-13 | |
| 8 | 43 | 13 | 2021-12-04 | Cincinnati | Houston | Conf Championship | W 35-20 | ||
| 9 | 44 | 14 | 2021-12-31 | Cincinnati | N | Alabama | CFB Semifinal | L 6-27 | Cotton Bowl |
| 8-1 |
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