| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 5 | 1 | 2021-09-04 | Iowa | Indiana | REG (Conf) | W 34-6 | ||
| 2 | 6 | 2 | 2021-09-11 | Iowa | @ | Iowa State | REG (Non-Conf) | W 27-17 | |
| 3 | 7 | 4 | 2021-09-25 | Iowa | Colorado State | REG (Non-Conf) | W 24-14 | ||
| 4 | 8 | 5 | 2021-10-01 | Iowa | @ | Maryland | REG (Conf) | W 51-14 | |
| 5 | 9 | 6 | 2021-10-09 | Iowa | Penn State | REG (Conf) | W 23-20 | ||
| 6 | 10 | 7 | 2021-10-16 | Iowa | Purdue | REG (Conf) | L 7-24 | ||
| 7 | 11 | 8 | 2021-10-30 | Iowa | @ | Wisconsin | REG (Conf) | L 7-27 | |
| 8 | 12 | 9 | 2021-11-06 | Iowa | @ | Northwestern | REG (Conf) | W 17-12 | |
| 9 | 13 | 10 | 2021-11-13 | Iowa | Minnesota | REG (Conf) | W 27-22 | ||
| 10 | 14 | 11 | 2021-11-20 | Iowa | Illinois | REG (Conf) | W 33-23 | ||
| 11 | 15 | 12 | 2021-11-26 | Iowa | @ | Nebraska | REG (Conf) | W 28-21 | |
| 12 | 16 | 13 | 2021-12-04 | Iowa | N | Michigan | Conf Championship | L 3-42 | |
| 13 | 17 | 14 | 2022-01-01 | Iowa | N | Kentucky | Bowl | L 17-20 | Citrus Bowl |
| 9-4 |
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