| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 16 | 1 | 2021-09-04 | Boston College | Colgate | REG (Non-Conf) | W 51-0 | |
| 2 | 17 | 2 | 2021-09-11 | Boston College | @ | Massachusetts | REG (Non-Conf) | W 45-28 |
| 3 | 18 | 3 | 2021-09-18 | Boston College | @ | Temple | REG (Non-Conf) | W 28-3 |
| 4 | 19 | 4 | 2021-09-25 | Boston College | Missouri | REG (Non-Conf) | W 41-34 | |
| 5 | 20 | 5 | 2021-10-02 | Boston College | @ | Clemson | REG (Conf) | L 13-19 |
| 6 | 21 | 6 | 2021-10-16 | Boston College | North Carolina State | REG (Conf) | L 7-33 | |
| 7 | 22 | 7 | 2021-10-23 | Boston College | @ | Louisville | REG (Conf) | L 14-28 |
| 8 | 23 | 8 | 2021-10-30 | Boston College | @ | Syracuse | REG (Conf) | L 6-21 |
| 9 | 24 | 9 | 2021-11-05 | Boston College | Virginia Tech | REG (Conf) | W 17-3 | |
| 10 | 25 | 10 | 2021-11-13 | Boston College | @ | Georgia Tech | REG (Conf) | W 41-30 |
| 11 | 26 | 11 | 2021-11-20 | Boston College | Florida State | REG (Conf) | L 23-26 | |
| 12 | 27 | 12 | 2021-11-27 | Boston College | Wake Forest | REG (Conf) | L 10-41 | |
| 6-6 |
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