| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | 10 | 2021-11-13 | Louisville | Syracuse | REG (Conf) | W 41-3 | ||
| 2 | 2 | 11 | 2021-11-18 | Louisville | @ | Duke | REG (Conf) | W 62-22 | |
| 3 | 3 | 12 | 2021-11-27 | Louisville | Kentucky | REG (Non-Conf) | L 21-52 | ||
| 4 | 4 | 13 | 2021-12-28 | Louisville | N | Air Force | Bowl | L 28-31 | First Responder Bowl |
| 2-2 |
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