| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 2 | 2021-09-11 | Oklahoma | Western Caro. | REG (Non-Conf) | W 76-0 | ||
| 2 | 3 | 3 | 2021-09-18 | Oklahoma | Nebraska | REG (Non-Conf) | W 23-16 | ||
| 3 | 4 | 4 | 2021-09-25 | Oklahoma | West Virginia | REG (Conf) | W 16-13 | ||
| 4 | 5 | 5 | 2021-10-02 | Oklahoma | @ | Kansas State | REG (Conf) | W 37-31 | |
| 5 | 6 | 6 | 2021-10-09 | Oklahoma | N | Texas | REG (Conf) | W 55-48 | |
| 6 | 7 | 7 | 2021-10-16 | Oklahoma | Texas Christian | REG (Conf) | W 52-31 | ||
| 7 | 8 | 8 | 2021-10-23 | Oklahoma | @ | Kansas | REG (Conf) | W 35-23 | |
| 8 | 9 | 9 | 2021-10-30 | Oklahoma | Texas Tech | REG (Conf) | W 52-21 | ||
| 9 | 10 | 10 | 2021-11-13 | Oklahoma | @ | Baylor | REG (Conf) | L 14-27 | |
| 10 | 11 | 11 | 2021-11-20 | Oklahoma | Iowa State | REG (Conf) | W 28-21 | ||
| 11 | 12 | 12 | 2021-11-27 | Oklahoma | @ | Oklahoma State | REG (Conf) | L 33-37 | |
| 12 | 13 | 13 | 2021-12-29 | Oklahoma | N | Oregon | Bowl | W 47-32 | Alamo Bowl |
| 10-2 |
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