44 Games
- Conference games only
- Click date for box score, if available
| Rk | Date | Time | Day | Winner | Pts | Loser | Pts | Notes | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 26, 2020 | 7:30 PM | Sat | Baylor | 47 | Kansas | 14 | ||
| 2 | Sep 26, 2020 | 1:30 PM | Sat | Iowa State | 37 | @ | Texas Christian | 34 | |
| 3 | Sep 26, 2020 | 12:00 PM | Sat | Kansas State | 38 | @ | (3) Oklahoma | 35 | |
| 4 | Sep 26, 2020 | 3:30 PM | Sat | (15) Oklahoma State | 27 | West Virginia | 13 | ||
| 5 | Sep 26, 2020 | 3:30 PM | Sat | (8) Texas | 63 | @ | Texas Tech | 56 | |
| Rk | Date | Time | Day | Winner | Pts | Loser | Pts | Notes | |
| 6 | Oct 3, 2020 | 7:30 PM | Sat | Iowa State | 37 | (18) Oklahoma | 30 | ||
| 7 | Oct 3, 2020 | 3:30 PM | Sat | Kansas State | 31 | Texas Tech | 21 | ||
| 8 | Oct 3, 2020 | 3:30 PM | Sat | (17) Oklahoma State | 47 | @ | Kansas | 7 | |
| 9 | Oct 3, 2020 | 12:00 PM | Sat | Texas Christian | 33 | @ | (9) Texas | 31 | |
| 10 | Oct 3, 2020 | 12:00 PM | Sat | West Virginia | 27 | Baylor | 21 | ||
| Rk | Date | Time | Day | Winner | Pts | Loser | Pts | Notes | |
| 11 | Oct 10, 2020 | 3:30 PM | Sat | (24) Iowa State | 31 | Texas Tech | 15 | ||
| 12 | Oct 10, 2020 | 4:00 PM | Sat | Kansas State | 21 | @ | Texas Christian | 14 | |
| 13 | Oct 10, 2020 | 12:00 PM | Sat | Oklahoma | 53 | N | (22) Texas | 45 | Cotton Bowl - Dallas, Texas |
| Rk | Date | Time | Day | Winner | Pts | Loser | Pts | Notes | |
| 14 | Oct 17, 2020 | 12:00 PM | Sat | West Virginia | 38 | Kansas | 17 | ||
| Rk | Date | Time | Day | Winner | Pts | Loser | Pts | Notes | |
| 15 | Oct 24, 2020 | 12:00 PM | Sat | (20) Kansas State | 55 | Kansas | 14 | ||
| 16 | Oct 24, 2020 | 12:00 PM | Sat | Oklahoma | 33 | @ | Texas Christian | 14 | |
| 17 | Oct 24, 2020 | 3:30 PM | Sat | (6) Oklahoma State | 24 | (17) Iowa State | 21 | ||
| 18 | Oct 24, 2020 | 3:30 PM | Sat | Texas | 27 | Baylor | 16 | ||
| 19 | Oct 24, 2020 | 5:30 PM | Sat | Texas Tech | 34 | West Virginia | 27 | ||
| Rk | Date | Time | Day | Winner | Pts | Loser | Pts | Notes | |
| 20 | Oct 31, 2020 | 12:00 PM | Sat | (23) Iowa State | 52 | @ | Kansas | 22 | |
| 21 | Oct 31, 2020 | 8:00 PM | Sat | (24) Oklahoma | 62 | @ | Texas Tech | 28 | |
| 22 | Oct 31, 2020 | 4:00 PM | Sat | Texas | 41 | @ | (6) Oklahoma State | 34 | |
| 23 | Oct 31, 2020 | 3:30 PM | Sat | Texas Christian | 33 | @ | Baylor | 23 | |
| 24 | Oct 31, 2020 | 12:00 PM | Sat | West Virginia | 37 | (16) Kansas State | 10 | ||
| Rk | Date | Time | Day | Winner | Pts | Loser | Pts | Notes | |
| 25 | Nov 7, 2020 | 7:00 PM | Sat | (17) Iowa State | 38 | Baylor | 31 | ||
| 26 | Nov 7, 2020 | 3:30 PM | Sat | (19) Oklahoma | 62 | Kansas | 9 | ||
| 27 | Nov 7, 2020 | 4:00 PM | Sat | (14) Oklahoma State | 20 | @ | Kansas State | 18 | |
| 28 | Nov 7, 2020 | 12:00 PM | Sat | (22) Texas | 17 | West Virginia | 13 | ||
| 29 | Nov 7, 2020 | 3:30 PM | Sat | Texas Christian | 34 | Texas Tech | 18 | ||
| Rk | Date | Time | Day | Winner | Pts | Loser | Pts | Notes | |
| 30 | Nov 14, 2020 | 4:00 PM | Sat | Texas Tech | 24 | Baylor | 23 | ||
| 31 | Nov 14, 2020 | 12:00 PM | Sat | West Virginia | 24 | Texas Christian | 6 | ||
| Rk | Date | Time | Day | Winner | Pts | Loser | Pts | Notes | |
| 32 | Nov 21, 2020 | 4:00 PM | Sat | (17) Iowa State | 45 | Kansas State | 0 | ||
| 33 | Nov 21, 2020 | 7:30 PM | Sat | (18) Oklahoma | 41 | (14) Oklahoma State | 13 | ||
| Rk | Date | Time | Day | Winner | Pts | Loser | Pts | Notes | |
| 34 | Nov 27, 2020 | 12:00 PM | Fri | (15) Iowa State | 23 | @ | (20) Texas | 20 | |
| 35 | Nov 28, 2020 | 7:00 PM | Sat | Baylor | 32 | Kansas State | 31 | ||
| 36 | Nov 28, 2020 | 12:00 PM | Sat | (21) Oklahoma State | 50 | Texas Tech | 44 | ||
| 37 | Nov 28, 2020 | 8:00 PM | Sat | Texas Christian | 59 | @ | Kansas | 23 | |
| Rk | Date | Time | Day | Winner | Pts | Loser | Pts | Notes | |
| 38 | Dec 5, 2020 | 3:30 PM | Sat | (12) Iowa State | 42 | West Virginia | 6 | ||
| 39 | Dec 5, 2020 | 8:00 PM | Sat | (13) Oklahoma | 27 | Baylor | 14 | ||
| 40 | Dec 5, 2020 | 12:00 PM | Sat | Texas | 69 | @ | Kansas State | 31 | |
| 41 | Dec 5, 2020 | 12:00 PM | Sat | Texas Christian | 29 | (19) Oklahoma State | 22 | ||
| 42 | Dec 5, 2020 | 12:00 PM | Sat | Texas Tech | 16 | Kansas | 13 | ||
| Rk | Date | Time | Day | Winner | Pts | Loser | Pts | Notes | |
| 43 | Dec 12, 2020 | 7:00 PM | Sat | Oklahoma State | 42 | @ | Baylor | 3 | |
| Rk | Date | Time | Day | Winner | Pts | Loser | Pts | Notes | |
| 44 | Dec 19, 2020 | 12:00 PM | Sat | (12) Oklahoma | 27 | N | (8) Iowa State | 21 | Big 12 Championship (Arlington, TX) |
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