| Pts | Pts | Date | |||
|---|---|---|---|---|---|
| Clemson | 45 | @ | Louisville | 10 | October 19, 2019 |
| Clemson | 77 | Louisville | 16 | November 3, 2018 | |
| Clemson | 47 | @ | Louisville | 21 | September 16, 2017 |
| Clemson | 42 | Louisville | 36 | October 1, 2016 | |
| Clemson | 20 | @ | Louisville | 17 | September 17, 2015 |
| 6 meetings: Clemson leads, 6-0-0 | |||||
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Louisville 2019 Leaders