Location: Clemson, South Carolina ▪ Colors: Burnt Orange & Northwest Purple
Stadium: Memorial Stadium (cap. 80,301)
Record: 111 Years, 648-443-44, .590 W-L% (Major School)
Conferences: ACC, Southern and Ind
Conference Champion: 16 Times
Bowls: 35 Bowls, 17-18, .486 W-L% (Major Bowls)
Ranked in AP Poll: 22 Times (Preseason), 26 Times (Final), 341 Weeks (Total)
| Record | Totals | Per Game | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rk | Opponent | From | To | G | W | L | T | Pct | PS | PA | Diff | PS | PA | Diff | Notes |
| 1 | Alabama | 1904 | 2008 | 14 | 2 | 12 | 0 | .143 | 97 | 390 | -293 | 6.9 | 27.9 | -20.9 | Game-by-Game |
| 2 | Army | 1937 | 1937 | 1 | 0 | 1 | 0 | .000 | 6 | 21 | -15 | 6.0 | 21.0 | -15.0 | Game-by-Game |
| 3 | Auburn | 1902 | 2012 | 48 | 13 | 33 | 2 | .292 | 481 | 938 | -457 | 10.0 | 19.5 | -9.5 | Game-by-Game |
| 4 | Ball State | 1992 | 2012 | 3 | 3 | 0 | 0 | 1.000 | 106 | 44 | 62 | 35.3 | 14.7 | 20.7 | Game-by-Game |
| 5 | Baylor | 1979 | 1979 | 1 | 0 | 1 | 0 | .000 | 18 | 24 | -6 | 18.0 | 24.0 | -6.0 | Game-by-Game |
| 6 | Boston College | 1939 | 2012 | 22 | 11 | 9 | 2 | .545 | 484 | 395 | 89 | 22.0 | 18.0 | 4.0 | Game-by-Game |
| 7 | California | 1991 | 1991 | 1 | 0 | 1 | 0 | .000 | 13 | 37 | -24 | 13.0 | 37.0 | -24.0 | Game-by-Game |
| 8 | Central Florida | 2001 | 2001 | 1 | 1 | 0 | 0 | 1.000 | 21 | 13 | 8 | 21.0 | 13.0 | 8.0 | Game-by-Game |
| 9 | Central Michigan | 2007 | 2007 | 1 | 1 | 0 | 0 | 1.000 | 70 | 14 | 56 | 70.0 | 14.0 | 56.0 | Game-by-Game |
| 10 | Centre | 1921 | 1923 | 3 | 0 | 3 | 0 | .000 | 7 | 63 | -56 | 2.3 | 21.0 | -18.7 | Game-by-Game |
| 11 | Citadel | 1909 | 1978 | 28 | 24 | 3 | 1 | .875 | 546 | 103 | 443 | 19.5 | 3.7 | 15.8 | Game-by-Game |
| 12 | Colorado | 1956 | 2005 | 2 | 1 | 1 | 0 | .500 | 40 | 37 | 3 | 20.0 | 18.5 | 1.5 | Game-by-Game |
| 13 | Cumberland | 1903 | 1903 | 1 | 0 | 0 | 1 | .500 | 11 | 11 | 0 | 11.0 | 11.0 | 0.0 | Game-by-Game |
| 14 | Davidson | 1906 | 1932 | 16 | 7 | 5 | 4 | .563 | 115 | 119 | -4 | 7.2 | 7.4 | -0.3 | Game-by-Game |
| 15 | Duke | 1934 | 2012 | 53 | 36 | 16 | 1 | .689 | 1319 | 836 | 483 | 24.9 | 15.8 | 9.1 | Game-by-Game |
| 16 | Duquesne | 1947 | 1950 | 4 | 4 | 0 | 0 | 1.000 | 162 | 53 | 109 | 40.5 | 13.3 | 27.3 | Game-by-Game |
| 17 | Erskine | 1919 | 1922 | 3 | 2 | 1 | 0 | .667 | 105 | 13 | 92 | 35.0 | 4.3 | 30.7 | Game-by-Game |
| 18 | Florida | 1911 | 1961 | 13 | 3 | 9 | 1 | .269 | 161 | 313 | -152 | 12.4 | 24.1 | -11.7 | Game-by-Game |
| 19 | Florida Atlantic | 2006 | 2006 | 1 | 1 | 0 | 0 | 1.000 | 54 | 6 | 48 | 54.0 | 6.0 | 48.0 | Game-by-Game |
| 20 | Florida State | 1970 | 2012 | 26 | 8 | 18 | 0 | .308 | 532 | 823 | -291 | 20.5 | 31.7 | -11.2 | Game-by-Game |
| Record | Totals | Per Game | |||||||||||||
| Rk | Opponent | From | To | G | W | L | T | Pct | PS | PA | Diff | PS | PA | Diff | Notes |
| 21 | Fordham | 1952 | 1952 | 1 | 0 | 0 | 1 | .500 | 12 | 12 | 0 | 12.0 | 12.0 | 0.0 | Game-by-Game |
| 22 | Furman | 1902 | 1979 | 42 | 30 | 9 | 3 | .750 | 1000 | 349 | 651 | 23.8 | 8.3 | 15.5 | Game-by-Game |
| 23 | George Washington | 1933 | 1942 | 5 | 3 | 1 | 1 | .700 | 59 | 13 | 46 | 11.8 | 2.6 | 9.2 | Game-by-Game |
| 24 | Georgia | 1902 | 2003 | 57 | 15 | 38 | 4 | .298 | 635 | 1090 | -455 | 11.1 | 19.1 | -8.0 | Game-by-Game |
| 25 | Georgia Pre-Flight | 1943 | 1943 | 1 | 0 | 1 | 0 | .000 | 6 | 32 | -26 | 6.0 | 32.0 | -26.0 | Game-by-Game |
| 26 | Georgia Tech | 1902 | 2012 | 76 | 24 | 50 | 2 | .329 | 1249 | 1616 | -367 | 16.4 | 21.3 | -4.8 | Game-by-Game |
| 27 | Illinois | 1990 | 1990 | 1 | 1 | 0 | 0 | 1.000 | 30 | 0 | 30 | 30.0 | 0.0 | 30.0 | Game-by-Game |
| 28 | Jacksonville Naval Air Station | 1942 | 1942 | 1 | 0 | 1 | 0 | .000 | 6 | 24 | -18 | 6.0 | 24.0 | -18.0 | Game-by-Game |
| 29 | Kentucky | 1925 | 2009 | 13 | 5 | 8 | 0 | .385 | 163 | 206 | -43 | 12.5 | 15.8 | -3.3 | Game-by-Game |
| 30 | Long Beach State | 1990 | 1990 | 1 | 1 | 0 | 0 | 1.000 | 59 | 0 | 59 | 59.0 | 0.0 | 59.0 | Game-by-Game |
| 31 | Louisiana State | 1958 | 2012 | 3 | 1 | 2 | 0 | .333 | 32 | 41 | -9 | 10.7 | 13.7 | -3.0 | Game-by-Game |
| 32 | Louisiana Tech | 2001 | 2006 | 3 | 3 | 0 | 0 | 1.000 | 133 | 37 | 96 | 44.3 | 12.3 | 32.0 | Game-by-Game |
| 33 | Louisiana-Monroe | 2007 | 2007 | 1 | 1 | 0 | 0 | 1.000 | 49 | 26 | 23 | 49.0 | 26.0 | 23.0 | Game-by-Game |
| 34 | Marshall | 1999 | 1999 | 1 | 0 | 1 | 0 | .000 | 10 | 13 | -3 | 10.0 | 13.0 | -3.0 | Game-by-Game |
| 35 | Maryland | 1952 | 2012 | 61 | 33 | 26 | 2 | .557 | 1260 | 1099 | 161 | 20.7 | 18.0 | 2.6 | Game-by-Game |
| 36 | Maryville (TN) | 1907 | 1907 | 1 | 1 | 0 | 0 | 1.000 | 35 | 0 | 35 | 35.0 | 0.0 | 35.0 | Game-by-Game |
| 37 | Mercer | 1910 | 1935 | 7 | 4 | 3 | 0 | .571 | 125 | 49 | 76 | 17.9 | 7.0 | 10.9 | Game-by-Game |
| 38 | Miami (FL) | 1945 | 2010 | 9 | 3 | 6 | 0 | .333 | 143 | 215 | -72 | 15.9 | 23.9 | -8.0 | Game-by-Game |
| 39 | Middle Tennessee State | 2003 | 2009 | 2 | 2 | 0 | 0 | 1.000 | 74 | 28 | 46 | 37.0 | 14.0 | 23.0 | Game-by-Game |
| 40 | Minnesota | 1985 | 1985 | 1 | 0 | 1 | 0 | .000 | 13 | 20 | -7 | 13.0 | 20.0 | -7.0 | Game-by-Game |
| Record | Totals | Per Game | |||||||||||||
| Rk | Opponent | From | To | G | W | L | T | Pct | PS | PA | Diff | PS | PA | Diff | Notes |
| 41 | Mississippi | 1928 | 1933 | 2 | 0 | 2 | 0 | .000 | 7 | 39 | -32 | 3.5 | 19.5 | -16.0 | Game-by-Game |
| 42 | Mississippi State | 1948 | 1999 | 3 | 1 | 1 | 1 | .500 | 35 | 31 | 4 | 11.7 | 10.3 | 1.3 | Game-by-Game |
| 43 | Missouri | 1948 | 2000 | 4 | 3 | 1 | 0 | .750 | 144 | 70 | 74 | 36.0 | 17.5 | 18.5 | Game-by-Game |
| 44 | Navy | 1939 | 1939 | 1 | 1 | 0 | 0 | 1.000 | 15 | 7 | 8 | 15.0 | 7.0 | 8.0 | Game-by-Game |
| 45 | Nebraska | 1981 | 2008 | 2 | 1 | 1 | 0 | .500 | 43 | 41 | 2 | 21.5 | 20.5 | 1.0 | Game-by-Game |
| 46 | Nevada-Las Vegas | 1993 | 1993 | 1 | 1 | 0 | 0 | 1.000 | 24 | 14 | 10 | 24.0 | 14.0 | 10.0 | Game-by-Game |
| 47 | Newberry | 1920 | 1923 | 3 | 3 | 0 | 0 | 1.000 | 115 | 6 | 109 | 38.3 | 2.0 | 36.3 | Game-by-Game |
| 48 | North Carolina | 1903 | 2011 | 53 | 34 | 18 | 1 | .651 | 1127 | 904 | 223 | 21.3 | 17.1 | 4.2 | Game-by-Game |
| 49 | North Carolina State | 1902 | 2012 | 78 | 50 | 28 | 0 | .641 | 1470 | 1230 | 240 | 18.8 | 15.8 | 3.1 | Game-by-Game |
| 50 | North Texas | 2010 | 2010 | 1 | 1 | 0 | 0 | 1.000 | 35 | 10 | 25 | 35.0 | 10.0 | 25.0 | Game-by-Game |
| 51 | Notre Dame | 1977 | 1979 | 2 | 1 | 1 | 0 | .500 | 33 | 31 | 2 | 16.5 | 15.5 | 1.0 | Game-by-Game |
| 52 | Ohio State | 1978 | 1978 | 1 | 1 | 0 | 0 | 1.000 | 17 | 15 | 2 | 17.0 | 15.0 | 2.0 | Game-by-Game |
| 53 | Oklahoma | 1963 | 1988 | 3 | 1 | 2 | 0 | .333 | 30 | 89 | -59 | 10.0 | 29.7 | -19.7 | Game-by-Game |
| 54 | Pacific | 1951 | 1951 | 1 | 0 | 1 | 0 | .000 | 7 | 21 | -14 | 7.0 | 21.0 | -14.0 | Game-by-Game |
| 55 | Penn State | 1987 | 1987 | 1 | 1 | 0 | 0 | 1.000 | 35 | 10 | 25 | 35.0 | 10.0 | 25.0 | Game-by-Game |
| 56 | Pittsburgh | 1977 | 1977 | 1 | 0 | 1 | 0 | .000 | 3 | 34 | -31 | 3.0 | 34.0 | -31.0 | Game-by-Game |
| 57 | Presbyterian | 1916 | 1945 | 14 | 11 | 2 | 1 | .821 | 314 | 48 | 266 | 22.4 | 3.4 | 19.0 | Game-by-Game |
| 58 | Rhodes | 1939 | 1939 | 1 | 1 | 0 | 0 | 1.000 | 21 | 6 | 15 | 21.0 | 6.0 | 15.0 | Game-by-Game |
| 59 | Rice | 1949 | 1980 | 7 | 4 | 3 | 0 | .571 | 102 | 107 | -5 | 14.6 | 15.3 | -0.7 | Game-by-Game |
| 60 | Samford | 1910 | 1912 | 3 | 3 | 0 | 0 | 1.000 | 98 | 0 | 98 | 32.7 | 0.0 | 32.7 | Game-by-Game |
| Record | Totals | Per Game | |||||||||||||
| Rk | Opponent | From | To | G | W | L | T | Pct | PS | PA | Diff | PS | PA | Diff | Notes |
| 61 | Sewanee | 1904 | 1904 | 1 | 0 | 1 | 0 | .000 | 5 | 11 | -6 | 5.0 | 11.0 | -6.0 | Game-by-Game |
| 62 | South Carolina | 1909 | 2012 | 104 | 61 | 39 | 4 | .606 | 1990 | 1487 | 503 | 19.1 | 14.3 | 4.8 | Game-by-Game |
| 63 | South Florida | 2010 | 2010 | 1 | 0 | 1 | 0 | .000 | 26 | 31 | -5 | 26.0 | 31.0 | -5.0 | Game-by-Game |
| 64 | Southern California | 1966 | 1966 | 1 | 0 | 1 | 0 | .000 | 0 | 30 | -30 | 0.0 | 30.0 | -30.0 | Game-by-Game |
| 65 | Stanford | 1986 | 1986 | 1 | 1 | 0 | 0 | 1.000 | 27 | 21 | 6 | 27.0 | 21.0 | 6.0 | Game-by-Game |
| 66 | Syracuse | 1995 | 1995 | 1 | 0 | 1 | 0 | .000 | 0 | 41 | -41 | 0.0 | 41.0 | -41.0 | Game-by-Game |
| 67 | Temple | 1991 | 2006 | 3 | 3 | 0 | 0 | 1.000 | 137 | 23 | 114 | 45.7 | 7.7 | 38.0 | Game-by-Game |
| 68 | Tennessee | 1902 | 2003 | 18 | 6 | 11 | 1 | .361 | 148 | 263 | -115 | 8.2 | 14.6 | -6.4 | Game-by-Game |
| 69 | Texas A&M | 1973 | 2005 | 4 | 1 | 3 | 0 | .250 | 46 | 105 | -59 | 11.5 | 26.3 | -14.8 | Game-by-Game |
| 70 | Texas Christian | 1959 | 2009 | 4 | 2 | 2 | 0 | .500 | 46 | 35 | 11 | 11.5 | 8.8 | 2.8 | Game-by-Game |
| 71 | Texas Tech | 2002 | 2002 | 1 | 0 | 1 | 0 | .000 | 15 | 55 | -40 | 15.0 | 55.0 | -40.0 | Game-by-Game |
| 72 | Texas-El Paso | 1997 | 1997 | 1 | 1 | 0 | 0 | 1.000 | 39 | 7 | 32 | 39.0 | 7.0 | 32.0 | Game-by-Game |
| 73 | Troy | 2011 | 2011 | 1 | 1 | 0 | 0 | 1.000 | 43 | 19 | 24 | 43.0 | 19.0 | 24.0 | Game-by-Game |
| 74 | Tulane | 1937 | 1981 | 10 | 4 | 6 | 0 | .400 | 146 | 175 | -29 | 14.6 | 17.5 | -2.9 | Game-by-Game |
| 75 | Utah State | 2004 | 2004 | 1 | 1 | 0 | 0 | 1.000 | 35 | 6 | 29 | 35.0 | 6.0 | 29.0 | Game-by-Game |
| 76 | Vanderbilt | 1905 | 1960 | 4 | 1 | 3 | 0 | .250 | 32 | 111 | -79 | 8.0 | 27.8 | -19.8 | Game-by-Game |
| 77 | Villanova | 1952 | 1978 | 2 | 1 | 1 | 0 | .500 | 38 | 14 | 24 | 19.0 | 7.0 | 12.0 | Game-by-Game |
| 78 | Virginia | 1955 | 2009 | 46 | 37 | 8 | 1 | .815 | 1182 | 672 | 510 | 25.7 | 14.6 | 11.1 | Game-by-Game |
| 79 | Virginia Military Institute | 1914 | 1944 | 12 | 5 | 5 | 2 | .500 | 194 | 123 | 71 | 16.2 | 10.3 | 5.9 | Game-by-Game |
| 80 | Virginia Tech | 1906 | 2012 | 31 | 19 | 11 | 1 | .629 | 574 | 453 | 121 | 18.5 | 14.6 | 3.9 | Game-by-Game |
| Record | Totals | Per Game | |||||||||||||
| Rk | Opponent | From | To | G | W | L | T | Pct | PS | PA | Diff | PS | PA | Diff | Notes |
| 81 | Wake Forest | 1933 | 2012 | 78 | 60 | 17 | 1 | .776 | 1918 | 1059 | 859 | 24.6 | 13.6 | 11.0 | Game-by-Game |
| 82 | West Virginia | 1989 | 2011 | 2 | 1 | 1 | 0 | .500 | 60 | 77 | -17 | 30.0 | 38.5 | -8.5 | Game-by-Game |
| 83 | Western Carolina | 1980 | 1980 | 1 | 1 | 0 | 0 | 1.000 | 17 | 10 | 7 | 17.0 | 10.0 | 7.0 | Game-by-Game |
| 84 | Wofford | 1917 | 1933 | 5 | 2 | 3 | 0 | .400 | 53 | 53 | 0 | 10.6 | 10.6 | 0.0 | Game-by-Game |