Record: 35-31-2, .529 W-L% (5th of 12) (Schedule and Results)
SRS: -6.86 (10th of 12) ▪ SOS: -7.52 (10th of 12)
Conference Champion: Bowling Green State and Miami (OH)
Ranked in Preseason AP Poll: 0
Ranked in Final AP Poll: 0
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oct 2, 1965 | Sat | Kent State | 27 | @ | Ohio | 10 | |
| 2 | Oct 2, 1965 | Sat | Marshall | 14 | Toledo | 0 | ||
| 3 | Oct 2, 1965 | Sat | Miami (OH) | 36 | @ | Western Michigan | 9 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 4 | Oct 9, 1965 | Sat | Bowling Green State | 21 | Western Michigan | 17 | ||
| 5 | Oct 9, 1965 | Sat | Kent State | 24 | Miami (OH) | 13 | ||
| 6 | Oct 9, 1965 | Sat | Toledo | 21 | Ohio | 7 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 7 | Oct 16, 1965 | Sat | Bowling Green State | 21 | Toledo | 14 | ||
| 8 | Oct 16, 1965 | Sat | Kent State | 10 | Western Michigan | 10 | ||
| 9 | Oct 16, 1965 | Sat | Miami (OH) | 28 | Marshall | 7 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 10 | Oct 23, 1965 | Sat | Bowling Green State | 7 | @ | Kent State | 6 | |
| 11 | Oct 23, 1965 | Sat | Miami (OH) | 34 | Ohio | 0 | ||
| 12 | Oct 23, 1965 | Sat | Western Michigan | 3 | @ | Toledo | 0 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 13 | Oct 30, 1965 | Sat | Miami (OH) | 23 | @ | Bowling Green State | 7 | |
| 14 | Oct 30, 1965 | Sat | Toledo | 7 | Kent State | 3 | ||
| 15 | Oct 30, 1965 | Sat | Western Michigan | 17 | Marshall | 14 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 16 | Nov 6, 1965 | Sat | Bowling Green State | 20 | @ | Marshall | 6 | |
| 17 | Nov 6, 1965 | Sat | Miami (OH) | 20 | Toledo | 16 | ||
| 18 | Nov 6, 1965 | Sat | Western Michigan | 17 | @ | Ohio | 6 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 19 | Nov 13, 1965 | Sat | Bowling Green State | 17 | @ | Ohio | 7 | |
| 20 | Nov 13, 1965 | Sat | Kent State | 33 | Marshall | 13 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 21 | Nov 20, 1965 | Sat | Marshall | 29 | Ohio | 14 |