Record: 180-156-4, .535 W-L% (2nd of 14) (Schedule and Results)
SRS: 2.16 (7th of 14) ▪ SOS: 0.83 (7th of 14)
Ranked in Preseason AP Poll: 4 (Florida State, Notre Dame, Penn State and Pittsburgh)
Ranked in Final AP Poll: 5 (Florida State, Miami (FL), Notre Dame, Penn State and Pittsburgh)
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
|---|---|---|---|---|---|---|---|---|
| 1 | Sep 6, 1980 | Sat | Miami (FL) | 24 | @ | Louisville | 10 | |
| 2 | Sep 6, 1980 | Sat | (18) Penn State | 54 | Colgate | 10 | ||
| 3 | Sep 6, 1980 | Sat | Southern Mississippi | 17 | @ | Tulane | 14 | |
| 4 | Sep 6, 1980 | Sat | West Virginia | 41 | Cincinnati | 27 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 5 | Sep 13, 1980 | Sat | Army | 28 | Holy Cross | 7 | ||
| 6 | Sep 13, 1980 | Sat | (10) Florida State | 52 | Louisville | 0 | ||
| 7 | Sep 13, 1980 | Sat | (3) Pittsburgh | 14 | Boston College | 6 | ||
| 8 | Sep 13, 1980 | Sat | Richmond | 21 | @ | Villanova | 7 | |
| 9 | Sep 13, 1980 | Sat | Rutgers | 21 | @ | Temple | 3 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 10 | Sep 20, 1980 | Sat | (9) Florida State | 63 | East Carolina | 7 | ||
| 11 | Sep 20, 1980 | Sat | Rutgers | 24 | Cincinnati | 7 | ||
| 12 | Sep 20, 1980 | Sat | Virginia Tech | 7 | William & Mary | 3 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 13 | Sep 27, 1980 | Sat | Georgia Tech | 17 | Memphis | 8 | ||
| 14 | Sep 27, 1980 | Sat | Miami (FL) | 10 | (9) Florida State | 9 | ||
| 15 | Sep 27, 1980 | Sat | Navy | 45 | William & Mary | 6 | ||
| 16 | Sep 27, 1980 | Sat | (6) Pittsburgh | 36 | Temple | 2 | ||
| 17 | Sep 27, 1980 | Sat | Southern Mississippi | 35 | @ | East Carolina | 7 | |
| 18 | Sep 27, 1980 | Sat | Villanova | 20 | Boston College | 9 | ||
| 19 | Sep 27, 1980 | Sat | West Virginia | 31 | Richmond | 28 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 20 | Oct 4, 1980 | Sat | Navy | 21 | Boston College | 0 | ||
| 21 | Oct 4, 1980 | Sat | Villanova | 23 | Cincinnati | 6 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 22 | Oct 11, 1980 | Sat | Colgate | 38 | Holy Cross | 7 | ||
| 23 | Oct 11, 1980 | Sat | East Carolina | 24 | @ | Richmond | 22 | |
| 24 | Oct 11, 1980 | Sat | (11) Florida State | 36 | (4) Pittsburgh | 22 | ||
| 25 | Oct 11, 1980 | Sat | Louisville | 38 | Memphis | 14 | ||
| 26 | Oct 11, 1980 | Sat | (7) Notre Dame | 32 | (13) Miami (FL) | 14 | ||
| 27 | Oct 11, 1980 | Sat | Syracuse | 31 | Temple | 7 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 28 | Oct 18, 1980 | Sat | (7) Florida State | 41 | Boston College | 7 | ||
| 29 | Oct 18, 1980 | Sat | Navy | 24 | Villanova | 15 | ||
| 30 | Oct 18, 1980 | Sat | North Texas | 29 | @ | Memphis | 10 | |
| 31 | Oct 18, 1980 | Sat | (5) Notre Dame | 30 | Army | 3 | ||
| 32 | Oct 18, 1980 | Sat | (12) Penn State | 24 | Syracuse | 7 | ||
| 33 | Oct 18, 1980 | Sat | (11) Pittsburgh | 42 | West Virginia | 14 | ||
| 34 | Oct 18, 1980 | Sat | (15) South Carolina | 49 | Cincinnati | 7 | ||
| 35 | Oct 18, 1980 | Sat | William & Mary | 21 | @ | Rutgers | 18 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 36 | Oct 25, 1980 | Sat | Boston College | 30 | Army | 14 | ||
| 37 | Oct 25, 1980 | Sat | (6) Florida State | 24 | @ | Memphis | 3 | |
| 38 | Oct 25, 1980 | Sat | (13) Penn State | 20 | @ | West Virginia | 15 | |
| 39 | Oct 25, 1980 | Sat | Richmond | 18 | Virginia Tech | 7 | ||
| 40 | Oct 25, 1980 | Sat | Syracuse | 17 | Rutgers | 9 | ||
| 41 | Oct 25, 1980 | Sat | Temple | 23 | Cincinnati | 7 | ||
| 42 | Oct 25, 1980 | Sat | Tulane | 31 | @ | Georgia Tech | 14 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 43 | Nov 1, 1980 | Sat | East Carolina | 31 | William & Mary | 23 | ||
| 44 | Nov 1, 1980 | Sat | (3) Notre Dame | 33 | Navy | 0 | East Rutherford, NJ | |
| 45 | Nov 1, 1980 | Sat | (13) Penn State | 27 | Miami (FL) | 12 | ||
| 46 | Nov 1, 1980 | Sat | (11) Pittsburgh | 43 | @ | Syracuse | 6 | |
| 47 | Nov 1, 1980 | Sat | Richmond | 24 | Cincinnati | 10 | ||
| 48 | Nov 1, 1980 | Sat | Rutgers | 37 | @ | Army | 21 | |
| 49 | Nov 1, 1980 | Sat | Temple | 17 | @ | Louisville | 12 | |
| 50 | Nov 1, 1980 | Sat | Virginia Tech | 34 | West Virginia | 11 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 51 | Nov 8, 1980 | Sat | Cincinnati | 14 | Memphis | 10 | ||
| 52 | Nov 8, 1980 | Sat | (3) Florida State | 31 | Virginia Tech | 7 | ||
| 53 | Nov 8, 1980 | Sat | Miami (FL) | 23 | East Carolina | 10 | ||
| 54 | Nov 8, 1980 | Sat | Navy | 6 | @ | Syracuse | 3 | |
| 55 | Nov 8, 1980 | Sat | (1) Notre Dame | 3 | Georgia Tech | 3 | ||
| 56 | Nov 8, 1980 | Sat | (9) Pittsburgh | 41 | Louisville | 23 | ||
| 57 | Nov 8, 1980 | Sat | West Virginia | 41 | @ | Temple | 28 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 58 | Nov 15, 1980 | Sat | Boston College | 27 | Syracuse | 16 | ||
| 59 | Nov 15, 1980 | Sat | Louisville | 20 | Cincinnati | 0 | ||
| 60 | Nov 15, 1980 | Sat | Navy | 19 | @ | Georgia Tech | 8 | |
| 61 | Nov 15, 1980 | Sat | North Texas | 26 | Louisiana-Monroe | 18 | ||
| 62 | Nov 15, 1980 | Sat | (9) Penn State | 50 | @ | Temple | 7 | |
| 63 | Nov 15, 1980 | Sat | (8) Pittsburgh | 45 | @ | Army | 7 | |
| 64 | Nov 15, 1980 | Sat | Southern Mississippi | 33 | Richmond | 12 | ||
| 65 | Nov 15, 1980 | Sat | Tulane | 21 | Memphis | 16 | ||
| 66 | Nov 15, 1980 | Sat | Villanova | 45 | @ | Holy Cross | 13 | |
| 67 | Nov 15, 1980 | Sat | West Virginia | 24 | @ | Rutgers | 15 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 68 | Nov 22, 1980 | Sat | Louisville | 6 | @ | Southern Mississippi | 3 | |
| 69 | Nov 22, 1980 | Sat | Miami (FL) | 26 | North Texas | 8 | ||
| 70 | Nov 22, 1980 | Sat | (6) Pittsburgh | 14 | @ | (7) Penn State | 9 | |
| 71 | Nov 22, 1980 | Sat | Richmond | 26 | William & Mary | 14 | ||
| 72 | Nov 22, 1980 | Sat | Rutgers | 35 | Colgate | 13 | ||
| 73 | Nov 22, 1980 | Sat | Syracuse | 20 | @ | West Virginia | 7 | |
| 74 | Nov 22, 1980 | Sat | Villanova | 23 | Temple | 7 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 75 | Nov 29, 1980 | Sat | Boston College | 27 | Holy Cross | 26 | ||
| 76 | Nov 29, 1980 | Sat | Navy | 33 | Army | 6 | Philadelphia, PA | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 77 | Dec 29, 1980 | Mon | (3) Pittsburgh | 37 | (18) South Carolina | 9 | Gator Bowl (Jacksonville, FL) | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 78 | Jan 2, 1981 | Fri | (20) Miami (FL) | 20 | Virginia Tech | 10 | Peach Bowl (Atlanta, GA) |