12 Games
| G | Date | Time | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 4, 2021 | 7:00 PM | Sat | Ohio | Syracuse | ACC | L | 9 | 29 | 0 | 1 | L 1 | ||
| 2 | Sep 11, 2021 | 2:00 PM | Sat | Ohio | Duquesne | Non-Major | L | 26 | 28 | 0 | 2 | L 2 | ||
| 3 | Sep 16, 2021 | 8:00 PM | Thu | Ohio | @ | Louisiana | Sun Belt | L | 14 | 49 | 0 | 3 | L 3 | |
| 4 | Sep 25, 2021 | 12:00 PM | Sat | Ohio | @ | Northwestern | Big Ten | L | 6 | 35 | 0 | 4 | L 4 | |
| 5 | Oct 2, 2021 | 3:30 PM | Sat | Ohio | @ | Akron | MAC | W | 34 | 17 | 1 | 4 | W 1 | |
| 6 | Oct 9, 2021 | 3:30 PM | Sat | Ohio | Central Michigan | MAC | L | 27 | 30 | 1 | 5 | L 1 | ||
| 7 | Oct 16, 2021 | 12:00 PM | Sat | Ohio | @ | Buffalo | MAC | L | 26 | 27 | 1 | 6 | L 2 | |
| 8 | Oct 23, 2021 | 1:00 PM | Sat | Ohio | Kent State | MAC | L | 27 | 34 | 1 | 7 | L 3 | ||
| 9 | Nov 2, 2021 | 7:30 PM | Tue | Ohio | Miami (OH) | MAC | W | 35 | 33 | 2 | 7 | W 1 | ||
| 10 | Nov 9, 2021 | 8:00 PM | Tue | Ohio | @ | Eastern Michigan | MAC | W | 34 | 26 | 3 | 7 | W 2 | |
| 11 | Nov 16, 2021 | 7:00 PM | Tue | Ohio | Toledo | MAC | L | 23 | 35 | 3 | 8 | L 1 | ||
| 12 | Nov 26, 2021 | 12:00 PM | Fri | Ohio | @ | Bowling Green | MAC | L | 10 | 21 | 3 | 9 | L 2 |
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