12 Games
| G | Date | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 4, 2010 | Sat | Louisiana | @ | (23) Georgia | SEC | L | 7 | 55 | 0 | 1 | L 1 | |
| 2 | Sep 11, 2010 | Sat | Louisiana | Arkansas State | Sun Belt | W | 31 | 24 | 1 | 1 | W 1 | ||
| 3 | Sep 25, 2010 | Sat | Louisiana | Middle Tennessee State | Sun Belt | L | 14 | 34 | 1 | 2 | L 1 | ||
| 4 | Oct 2, 2010 | Sat | Louisiana | @ | North Texas | Sun Belt | W | 28 | 27 | 2 | 2 | W 1 | |
| 5 | Oct 8, 2010 | Fri | Louisiana | (22) Oklahoma State | Big 12 | L | 28 | 54 | 2 | 3 | L 1 | ||
| 6 | Oct 16, 2010 | Sat | Louisiana | @ | Troy | Sun Belt | L | 24 | 31 | 2 | 4 | L 2 | |
| 7 | Oct 23, 2010 | Sat | Louisiana | Western Kentucky | Sun Belt | L | 21 | 54 | 2 | 5 | L 3 | ||
| 8 | Oct 30, 2010 | Sat | Louisiana | @ | Ohio | MAC | L | 31 | 38 | 2 | 6 | L 4 | |
| 9 | Nov 6, 2010 | Sat | Louisiana | @ | Ole Miss | SEC | L | 21 | 43 | 2 | 7 | L 5 | |
| 10 | Nov 13, 2010 | Sat | Louisiana | @ | Florida Atlantic | Sun Belt | L | 23 | 24 | 2 | 8 | L 6 | |
| 11 | Nov 20, 2010 | Sat | Louisiana | Florida International | Sun Belt | L | 17 | 38 | 2 | 9 | L 7 | ||
| 12 | Nov 27, 2010 | Sat | Louisiana | @ | Louisiana-Monroe | Sun Belt | W | 23 | 22 | 3 | 9 | W 1 |
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