12 Games
| G | Date | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 2, 2010 | Thu | Indiana | Towson | Non-Major | W | 51 | 17 | 1 | 0 | W 1 | ||
| 2 | Sep 18, 2010 | Sat | Indiana | @ | Western Kentucky | Sun Belt | W | 38 | 21 | 2 | 0 | W 2 | |
| 3 | Sep 25, 2010 | Sat | Indiana | Akron | MAC | W | 35 | 20 | 3 | 0 | W 3 | ||
| 4 | Oct 2, 2010 | Sat | Indiana | (19) Michigan | Big Ten | L | 35 | 42 | 3 | 1 | L 1 | ||
| 5 | Oct 9, 2010 | Sat | Indiana | @ | (2) Ohio State | Big Ten | L | 10 | 38 | 3 | 2 | L 2 | |
| 6 | Oct 16, 2010 | Sat | Indiana | Arkansas State | Sun Belt | W | 36 | 34 | 4 | 2 | W 1 | ||
| 7 | Oct 23, 2010 | Sat | Indiana | @ | Illinois | Big Ten | L | 13 | 43 | 4 | 3 | L 1 | |
| 8 | Oct 30, 2010 | Sat | Indiana | Northwestern | Big Ten | L | 17 | 20 | 4 | 4 | L 2 | ||
| 9 | Nov 6, 2010 | Sat | Indiana | (15) Iowa | Big Ten | L | 13 | 18 | 4 | 5 | L 3 | ||
| 10 | Nov 13, 2010 | Sat | Indiana | @ | (6) Wisconsin | Big Ten | L | 20 | 83 | 4 | 6 | L 4 | |
| 11 | Nov 20, 2010 | Sat | Indiana | N | Penn State | Big Ten | L | 24 | 41 | 4 | 7 | L 5 | |
| 12 | Nov 27, 2010 | Sat | Indiana | @ | Purdue | Big Ten | W | 34 | 31 | 5 | 7 | W 1 |
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