Anne Vrana-O'Brien began to run track at Fremont High School in California, where she was coached by Otto Anderson, a 1924 Olympian. She later ran hurdles for the Los Angeles Athletic Club, although she also trained with the Pasadena Athletic Club. She was the 1936 AAU Champion in the hurdles, which doubled as the US Olympic Trials. In 1932 she set a world record in the 80 metre hurdles with 11.8. Vrana was married in 1930 to a high school sweetheart who also ran track at Fremont. She competed at the 1932 Olympic Trials but did not make the team. Vrana-O'Brien returned to Southern California after the 1936 Olympics, where her husband worked in oil fields. He was able to buy a few wells and they did quite well. Anne Vrana-O'Brien raised her family, did some volunteer coaching, and spent some time counseling youths at the Orange County Juvenile Hall.
Personal Bests: 100 – unknown; 80H – 11.8 (1932).