Reginald Marsh was born in Paris and was a notable painter of New York City scenes. Both of his parents Alice Randall and Frederick Dana Marsh (1872-1961) were American painters who lived in Paris. The family was wealthy and moved back to New Jersey when he was 2-years-old. Marsh studied at Yale and then moved to New York, where he began work as an illustrator.
Marsh later devoted himself to etchings, and oil and watercolor painting. His main motivation were the street people of New York. One of his most famous students in his Department at the Art Students League in New York was the renowned pop-artist Roy Lichtenstein.