Location: Louisville, Kentucky ▪ Colors: Red, Black & White
Stadium: Papa John's Cardinal Stadium (cap. 42,000)
Record*: 51 Years, 301-269-7, .528 W-L% (Major School)
*W-L-T adjusted to 303-267-7 by NCAA.
Conferences: Big East, CUSA, MVC and Ind
Conference Champion: 7 Times
Bowls: 16 Bowls, 7-8-1, .469 W-L% (Major Bowls)
Ranked in AP Poll: 5 Times (Preseason), 8 Times (Final), 96 Weeks (Total)
| Record | Totals | Per Game | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rk | Opponent | From | To | G | W | L | T | Pct | PS | PA | Diff | PS | PA | Diff | Notes |
| 1 | Akron | 1987 | 1987 | 1 | 1 | 0 | 0 | 1.000 | 31 | 10 | 21 | 31.0 | 10.0 | 21.0 | Game-by-Game |
| 2 | Alabama | 1976 | 1990 | 3 | 1 | 2 | 0 | .333 | 43 | 86 | -43 | 14.3 | 28.7 | -14.3 | Game-by-Game |
| 3 | Alabama-Birmingham | 1999 | 2002 | 3 | 3 | 0 | 0 | 1.000 | 102 | 52 | 50 | 34.0 | 17.3 | 16.7 | Game-by-Game |
| 4 | Arizona State | 1992 | 1994 | 3 | 2 | 1 | 0 | .667 | 60 | 58 | 2 | 20.0 | 19.3 | 0.7 | Game-by-Game |
| 5 | Arkansas State | 2009 | 2010 | 2 | 2 | 0 | 0 | 1.000 | 55 | 37 | 18 | 27.5 | 18.5 | 9.0 | Game-by-Game |
| 6 | Army | 1983 | 2004 | 9 | 6 | 3 | 0 | .667 | 328 | 218 | 110 | 36.4 | 24.2 | 12.2 | Game-by-Game |
| 7 | Auburn | 1974 | 1974 | 1 | 0 | 1 | 0 | .000 | 3 | 16 | -13 | 3.0 | 16.0 | -13.0 | Game-by-Game |
| 8 | Baylor | 1996 | 1996 | 1 | 0 | 1 | 0 | .000 | 13 | 14 | -1 | 13.0 | 14.0 | -1.0 | Game-by-Game |
| 9 | Boise State | 1999 | 2004 | 2 | 1 | 1 | 0 | .500 | 75 | 74 | 1 | 37.5 | 37.0 | 0.5 | Game-by-Game |
| 10 | Boston College | 1986 | 1998 | 6 | 3 | 3 | 0 | .500 | 129 | 169 | -40 | 21.5 | 28.2 | -6.7 | Game-by-Game |
| 11 | Brigham Young | 2001 | 2001 | 1 | 1 | 0 | 0 | 1.000 | 28 | 10 | 18 | 28.0 | 10.0 | 18.0 | Game-by-Game |
| 12 | Chattanooga | 1975 | 1975 | 1 | 1 | 0 | 0 | 1.000 | 6 | 3 | 3 | 6.0 | 3.0 | 3.0 | Game-by-Game |
| 13 | Cincinnati | 1966 | 2012 | 44 | 21 | 22 | 1 | .489 | 981 | 967 | 14 | 22.3 | 22.0 | 0.3 | Game-by-Game |
| 14 | Colorado State | 2000 | 2002 | 3 | 1 | 2 | 0 | .333 | 57 | 60 | -3 | 19.0 | 20.0 | -1.0 | Game-by-Game |
| 15 | Connecticut | 2000 | 2012 | 9 | 5 | 4 | 0 | .556 | 262 | 187 | 75 | 29.1 | 20.8 | 8.3 | Game-by-Game |
| 16 | Dayton | 1962 | 1975 | 14 | 9 | 5 | 0 | .643 | 295 | 200 | 95 | 21.1 | 14.3 | 6.8 | Game-by-Game |
| 17 | Drake | 1971 | 1979 | 8 | 5 | 3 | 0 | .625 | 189 | 154 | 35 | 23.6 | 19.3 | 4.4 | Game-by-Game |
| 18 | Duke | 2002 | 2002 | 1 | 1 | 0 | 0 | 1.000 | 40 | 3 | 37 | 40.0 | 3.0 | 37.0 | Game-by-Game |
| 19 | East Carolina | 1965 | 2004 | 10 | 6 | 4 | 0 | .600 | 351 | 258 | 93 | 35.1 | 25.8 | 9.3 | Game-by-Game |
| 20 | Eastern Michigan | 1999 | 1999 | 1 | 1 | 0 | 0 | 1.000 | 45 | 10 | 35 | 45.0 | 10.0 | 35.0 | Game-by-Game |
| Record | Totals | Per Game | |||||||||||||
| Rk | Opponent | From | To | G | W | L | T | Pct | PS | PA | Diff | PS | PA | Diff | Notes |
| 21 | Florida | 1980 | 2012 | 3 | 1 | 2 | 0 | .333 | 50 | 67 | -17 | 16.7 | 22.3 | -5.7 | Game-by-Game |
| 22 | Florida Atlantic | 2005 | 2005 | 1 | 1 | 0 | 0 | 1.000 | 61 | 10 | 51 | 61.0 | 10.0 | 51.0 | Game-by-Game |
| 23 | Florida International | 2011 | 2012 | 2 | 1 | 1 | 0 | .500 | 45 | 45 | 0 | 22.5 | 22.5 | 0.0 | Game-by-Game |
| 24 | Florida State | 1970 | 2002 | 11 | 1 | 10 | 0 | .091 | 96 | 382 | -286 | 8.7 | 34.7 | -26.0 | Game-by-Game |
| 25 | Furman | 1973 | 1973 | 1 | 1 | 0 | 0 | 1.000 | 35 | 14 | 21 | 35.0 | 14.0 | 21.0 | Game-by-Game |
| 26 | Houston | 1962 | 2004 | 12 | 6 | 6 | 0 | .500 | 364 | 354 | 10 | 30.3 | 29.5 | 0.8 | Game-by-Game |
| 27 | Illinois | 1986 | 2001 | 5 | 2 | 3 | 0 | .400 | 107 | 121 | -14 | 21.4 | 24.2 | -2.8 | Game-by-Game |
| 28 | Indiana | 1985 | 1986 | 2 | 0 | 2 | 0 | .000 | 28 | 62 | -34 | 14.0 | 31.0 | -17.0 | Game-by-Game |
| 29 | Indiana State | 1977 | 1984 | 6 | 5 | 1 | 0 | .833 | 175 | 122 | 53 | 29.2 | 20.3 | 8.8 | Game-by-Game |
| 30 | Kansas | 1980 | 1990 | 3 | 3 | 0 | 0 | 1.000 | 78 | 53 | 25 | 26.0 | 17.7 | 8.3 | Game-by-Game |
| 31 | Kansas State | 2006 | 2008 | 2 | 2 | 0 | 0 | 1.000 | 62 | 35 | 27 | 31.0 | 17.5 | 13.5 | Game-by-Game |
| 32 | Kent State | 1962 | 1973 | 11 | 5 | 6 | 0 | .455 | 173 | 170 | 3 | 15.7 | 15.5 | 0.3 | Game-by-Game |
| 33 | Kentucky | 1994 | 2012 | 19 | 11 | 8 | 0 | .579 | 565 | 472 | 93 | 29.7 | 24.8 | 4.9 | Game-by-Game |
| 34 | Long Beach State | 1970 | 1981 | 2 | 1 | 0 | 1 | .750 | 59 | 37 | 22 | 29.5 | 18.5 | 11.0 | Game-by-Game |
| 35 | Louisiana Tech | 1977 | 1977 | 1 | 0 | 1 | 0 | .000 | 14 | 24 | -10 | 14.0 | 24.0 | -10.0 | Game-by-Game |
| 36 | Louisiana-Monroe | 1975 | 1995 | 4 | 2 | 2 | 0 | .500 | 92 | 62 | 30 | 23.0 | 15.5 | 7.5 | Game-by-Game |
| 37 | Marshall | 1962 | 2011 | 14 | 10 | 4 | 0 | .714 | 364 | 215 | 149 | 26.0 | 15.4 | 10.6 | Game-by-Game |
| 38 | Maryland | 1978 | 1995 | 4 | 1 | 3 | 0 | .250 | 71 | 79 | -8 | 17.8 | 19.8 | -2.0 | Game-by-Game |
| 39 | Memphis | 1962 | 2010 | 39 | 23 | 16 | 0 | .590 | 871 | 964 | -93 | 22.3 | 24.7 | -2.4 | Game-by-Game |
| 40 | Miami (FL) | 1979 | 2006 | 8 | 1 | 7 | 0 | .125 | 141 | 249 | -108 | 17.6 | 31.1 | -13.5 | Game-by-Game |
| Record | Totals | Per Game | |||||||||||||
| Rk | Opponent | From | To | G | W | L | T | Pct | PS | PA | Diff | PS | PA | Diff | Notes |
| 41 | Miami (OH) | 2003 | 2003 | 1 | 0 | 1 | 0 | .000 | 28 | 49 | -21 | 28.0 | 49.0 | -21.0 | Game-by-Game |
| 42 | Michigan State | 1993 | 1996 | 3 | 2 | 1 | 0 | .667 | 55 | 57 | -2 | 18.3 | 19.0 | -0.7 | Game-by-Game |
| 43 | Middle Tennessee State | 2006 | 2008 | 3 | 3 | 0 | 0 | 1.000 | 144 | 82 | 62 | 48.0 | 27.3 | 20.7 | Game-by-Game |
| 44 | Mississippi State | 1973 | 1976 | 4 | 0 | 4 | 0 | .000 | 49 | 132 | -83 | 12.3 | 33.0 | -20.8 | Game-by-Game |
| 45 | Missouri | 1981 | 1981 | 1 | 0 | 1 | 0 | .000 | 3 | 34 | -31 | 3.0 | 34.0 | -31.0 | Game-by-Game |
| 46 | Navy | 1993 | 1994 | 2 | 2 | 0 | 0 | 1.000 | 63 | 14 | 49 | 31.5 | 7.0 | 24.5 | Game-by-Game |
| 47 | New Mexico State | 2001 | 2001 | 1 | 1 | 0 | 0 | 1.000 | 45 | 24 | 21 | 45.0 | 24.0 | 21.0 | Game-by-Game |
| 48 | North Carolina | 1988 | 2012 | 7 | 4 | 3 | 0 | .571 | 207 | 141 | 66 | 29.6 | 20.1 | 9.4 | Game-by-Game |
| 49 | North Carolina State | 1994 | 2011 | 3 | 2 | 1 | 0 | .667 | 88 | 55 | 33 | 29.3 | 18.3 | 11.0 | Game-by-Game |
| 50 | North Texas | 1962 | 1995 | 14 | 6 | 8 | 0 | .429 | 296 | 255 | 41 | 21.1 | 18.2 | 2.9 | Game-by-Game |
| 51 | Northern Illinois | 1977 | 1996 | 3 | 3 | 0 | 0 | 1.000 | 99 | 24 | 75 | 33.0 | 8.0 | 25.0 | Game-by-Game |
| 52 | Northwestern State | 1978 | 1978 | 1 | 1 | 0 | 0 | 1.000 | 51 | 7 | 44 | 51.0 | 7.0 | 44.0 | Game-by-Game |
| 53 | Ohio State | 1991 | 1992 | 2 | 0 | 2 | 0 | .000 | 34 | 43 | -9 | 17.0 | 21.5 | -4.5 | Game-by-Game |
| 54 | Oklahoma | 1997 | 1999 | 2 | 0 | 2 | 0 | .000 | 35 | 77 | -42 | 17.5 | 38.5 | -21.0 | Game-by-Game |
| 55 | Oklahoma State | 1981 | 1982 | 2 | 1 | 1 | 0 | .500 | 39 | 41 | -2 | 19.5 | 20.5 | -1.0 | Game-by-Game |
| 56 | Oregon State | 2005 | 2010 | 2 | 1 | 1 | 0 | .500 | 91 | 62 | 29 | 45.5 | 31.0 | 14.5 | Game-by-Game |
| 57 | Penn State | 1996 | 1997 | 2 | 0 | 2 | 0 | .000 | 28 | 81 | -53 | 14.0 | 40.5 | -26.5 | Game-by-Game |
| 58 | Pittsburgh | 1976 | 2012 | 16 | 8 | 8 | 0 | .500 | 366 | 471 | -105 | 22.9 | 29.4 | -6.6 | Game-by-Game |
| 59 | Purdue | 1987 | 1987 | 1 | 0 | 0 | 1 | .500 | 22 | 22 | 0 | 22.0 | 22.0 | 0.0 | Game-by-Game |
| 60 | Richmond | 1982 | 1982 | 1 | 1 | 0 | 0 | 1.000 | 35 | 0 | 35 | 35.0 | 0.0 | 35.0 | Game-by-Game |
| Record | Totals | Per Game | |||||||||||||
| Rk | Opponent | From | To | G | W | L | T | Pct | PS | PA | Diff | PS | PA | Diff | Notes |
| 61 | Rutgers | 1976 | 2012 | 12 | 5 | 7 | 0 | .417 | 254 | 356 | -102 | 21.2 | 29.7 | -8.5 | Game-by-Game |
| 62 | San Jose State | 1990 | 1993 | 2 | 1 | 0 | 1 | .750 | 41 | 34 | 7 | 20.5 | 17.0 | 3.5 | Game-by-Game |
| 63 | South Florida | 2003 | 2012 | 10 | 5 | 5 | 0 | .500 | 259 | 275 | -16 | 25.9 | 27.5 | -1.6 | Game-by-Game |
| 64 | Southern Illinois | 1972 | 1972 | 1 | 1 | 0 | 0 | 1.000 | 20 | 16 | 4 | 20.0 | 16.0 | 4.0 | Game-by-Game |
| 65 | Southern Methodist | 1983 | 1984 | 2 | 0 | 2 | 0 | .000 | 13 | 65 | -52 | 6.5 | 32.5 | -26.0 | Game-by-Game |
| 66 | Southern Mississippi | 1978 | 2012 | 26 | 10 | 15 | 1 | .404 | 473 | 723 | -250 | 18.2 | 27.8 | -9.6 | Game-by-Game |
| 67 | Syracuse | 1985 | 2012 | 12 | 6 | 6 | 0 | .500 | 268 | 287 | -19 | 22.3 | 23.9 | -1.6 | Game-by-Game |
| 68 | Tampa | 1971 | 1972 | 2 | 2 | 0 | 0 | 1.000 | 38 | 24 | 14 | 19.0 | 12.0 | 7.0 | Game-by-Game |
| 69 | Temple | 1980 | 2012 | 6 | 3 | 3 | 0 | .500 | 161 | 125 | 36 | 26.8 | 20.8 | 6.0 | Game-by-Game |
| 70 | Tennessee | 1987 | 1993 | 3 | 0 | 3 | 0 | .000 | 31 | 114 | -83 | 10.3 | 38.0 | -27.7 | Game-by-Game |
| 71 | Texas | 1993 | 1994 | 2 | 1 | 1 | 0 | .500 | 57 | 40 | 17 | 28.5 | 20.0 | 8.5 | Game-by-Game |
| 72 | Texas A&M | 1992 | 1994 | 3 | 0 | 3 | 0 | .000 | 35 | 108 | -73 | 11.7 | 36.0 | -24.3 | Game-by-Game |
| 73 | Texas Christian | 2001 | 2004 | 4 | 1 | 3 | 0 | .250 | 136 | 141 | -5 | 34.0 | 35.3 | -1.3 | Game-by-Game |
| 74 | Texas-El Paso | 2003 | 2003 | 1 | 1 | 0 | 0 | 1.000 | 42 | 14 | 28 | 42.0 | 14.0 | 28.0 | Game-by-Game |
| 75 | Toledo | 1981 | 1981 | 1 | 1 | 0 | 0 | 1.000 | 31 | 6 | 25 | 31.0 | 6.0 | 25.0 | Game-by-Game |
| 76 | Tulane | 1986 | 2004 | 11 | 9 | 2 | 0 | .818 | 404 | 287 | 117 | 36.7 | 26.1 | 10.6 | Game-by-Game |
| 77 | Tulsa | 1962 | 1994 | 26 | 12 | 14 | 0 | .462 | 492 | 592 | -100 | 18.9 | 22.8 | -3.8 | Game-by-Game |
| 78 | Utah | 1997 | 2009 | 4 | 0 | 4 | 0 | .000 | 92 | 146 | -54 | 23.0 | 36.5 | -13.5 | Game-by-Game |
| 79 | Vanderbilt | 1971 | 1974 | 2 | 0 | 1 | 1 | .250 | 0 | 44 | -44 | 0.0 | 22.0 | -22.0 | Game-by-Game |
| 80 | Virginia | 1988 | 1989 | 2 | 1 | 1 | 0 | .500 | 45 | 44 | 1 | 22.5 | 22.0 | 0.5 | Game-by-Game |
| Record | Totals | Per Game | |||||||||||||
| Rk | Opponent | From | To | G | W | L | T | Pct | PS | PA | Diff | PS | PA | Diff | Notes |
| 81 | Virginia Tech | 1979 | 2005 | 7 | 2 | 5 | 0 | .286 | 102 | 183 | -81 | 14.6 | 26.1 | -11.6 | Game-by-Game |
| 82 | Wake Forest | 2006 | 2006 | 1 | 1 | 0 | 0 | 1.000 | 24 | 13 | 11 | 24.0 | 13.0 | 11.0 | Game-by-Game |
| 83 | West Texas A&M | 1973 | 1975 | 3 | 2 | 1 | 0 | .667 | 54 | 66 | -12 | 18.0 | 22.0 | -4.0 | Game-by-Game |
| 84 | West Virginia | 1984 | 2011 | 13 | 3 | 10 | 0 | .231 | 299 | 419 | -120 | 23.0 | 32.2 | -9.2 | Game-by-Game |
| 85 | Western Michigan | 1962 | 1965 | 4 | 2 | 2 | 0 | .500 | 68 | 55 | 13 | 17.0 | 13.8 | 3.3 | Game-by-Game |
| 86 | Wichita State | 1962 | 1978 | 17 | 13 | 4 | 0 | .765 | 406 | 264 | 142 | 23.9 | 15.5 | 8.4 | Game-by-Game |
| 87 | William & Mary | 1977 | 1978 | 2 | 1 | 1 | 0 | .500 | 40 | 42 | -2 | 20.0 | 21.0 | -1.0 | Game-by-Game |
| 88 | Wyoming | 1988 | 1995 | 4 | 1 | 3 | 0 | .250 | 81 | 118 | -37 | 20.3 | 29.5 | -9.3 | Game-by-Game |
| 89 | Xavier | 1962 | 1962 | 1 | 0 | 1 | 0 | .000 | 12 | 13 | -1 | 12.0 | 13.0 | -1.0 | Game-by-Game |