9 Games
| G | Date | Day | School | Opponent | Conf | Pts | Opp | W | L | T | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Oct 1, 1921 | Sat | Clemson | @ | Centre | Ind | L | 0 | 14 | 0 | 1 | 0 | L 1 | |
| 2 | Oct 7, 1921 | Fri | Clemson | Presbyterian | Ind | W | 34 | 0 | 1 | 1 | 0 | W 1 | ||
| 3 | Oct 14, 1921 | Fri | Clemson | @ | Auburn | Southern | L | 0 | 56 | 1 | 2 | 0 | L 1 | |
| 4 | Oct 21, 1921 | Fri | Clemson | @ | Furman | Ind | T | 0 | 0 | 1 | 2 | 1 | T 1 | |
| 5 | Oct 27, 1921 | Thu | Clemson | @ | South Carolina | Ind | L | 0 | 21 | 1 | 3 | 1 | L 1 | |
| 6 | Nov 5, 1921 | Sat | Clemson | @ | Georgia Tech | Southern | L | 7 | 48 | 1 | 4 | 1 | L 2 | |
| 7 | Nov 10, 1921 | Thu | Clemson | N | The Citadel | Ind | T | 7 | 7 | 1 | 4 | 2 | T 1 | |
| 8 | Nov 18, 1921 | Fri | Clemson | Erskine | Ind | L | 0 | 13 | 1 | 5 | 2 | L 1 | ||
| 9 | Nov 25, 1921 | Fri | Clemson | @ | Georgia | Southern | L | 0 | 28 | 1 | 6 | 2 | L 2 |
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