Record: 40-43-5, .483 W-L% (9th of 14) (Schedule and Results)
SRS: -7.51 (11th of 14) ▪ SOS: -7.32 (12th of 14)
Conference Champion: Furman
Ranked in Preseason AP Poll: 0
Ranked in Final AP Poll: 0
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
|---|---|---|---|---|---|---|---|---|
| 1 | Sep 6, 1980 | Sat | Western Carolina | 16 | Virginia Military Institute | 14 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 2 | Sep 13, 1980 | Sat | Appalachian State | 17 | Citadel | 14 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 3 | Sep 20, 1980 | Sat | Chattanooga | 14 | Appalachian State | 7 | ||
| 4 | Sep 20, 1980 | Sat | Furman | 28 | @ | Western Carolina | 14 | |
| 5 | Sep 20, 1980 | Sat | Virginia Military Institute | 17 | Marshall | 3 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 6 | Sep 27, 1980 | Sat | Appalachian State | 42 | East Tennessee State | 15 | ||
| 7 | Sep 27, 1980 | Sat | Citadel | 29 | Chattanooga | 13 | ||
| 8 | Sep 27, 1980 | Sat | Furman | 21 | Virginia Military Institute | 16 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 9 | Oct 4, 1980 | Sat | Appalachian State | 23 | @ | Marshall | 6 | |
| 10 | Oct 4, 1980 | Sat | Citadel | 28 | Virginia Military Institute | 0 | ||
| 11 | Oct 4, 1980 | Sat | Furman | 42 | @ | Chattanooga | 28 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 12 | Oct 11, 1980 | Sat | Chattanooga | 55 | @ | Virginia Military Institute | 10 | |
| 13 | Oct 11, 1980 | Sat | Citadel | 28 | @ | Western Carolina | 21 | |
| 14 | Oct 11, 1980 | Sat | Furman | 33 | @ | East Tennessee State | 21 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 15 | Oct 18, 1980 | Sat | Chattanooga | 21 | @ | Marshall | 11 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 16 | Oct 25, 1980 | Sat | Chattanooga | 26 | East Tennessee State | 14 | ||
| 17 | Oct 25, 1980 | Sat | Furman | 21 | @ | Appalachian State | 20 | |
| 18 | Oct 25, 1980 | Sat | Marshall | 13 | Western Carolina | 13 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 19 | Nov 1, 1980 | Sat | Appalachian State | 27 | Western Carolina | 24 | ||
| 20 | Nov 1, 1980 | Sat | Furman | 35 | @ | Marshall | 0 | Charleston, WV |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 21 | Nov 8, 1980 | Sat | Appalachian State | 16 | Virginia Military Institute | 16 | ||
| 22 | Nov 8, 1980 | Sat | Chattanooga | 39 | Western Carolina | 14 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 23 | Nov 15, 1980 | Sat | Western Carolina | 20 | @ | East Tennessee State | 17 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 24 | Nov 22, 1980 | Sat | East Tennessee State | 21 | Marshall | 16 | ||
| 25 | Nov 22, 1980 | Sat | Furman | 28 | Citadel | 15 |