Record: 65-81, .445 W-L% (11th of 12) (Schedule and Results)
SRS: -11.26 (12th of 12) ▪ SOS: -8.68 (12th of 12)
Division Champions: Marshall (East) and Western Michigan (West)
Conference Champion: Marshall (Won Championship Game 34-30)
Ranked in Preseason AP Poll: 0
Ranked in Final AP Poll: 1 (Marshall)
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
|---|---|---|---|---|---|---|---|---|
| 1 | Sep 11, 1999 | Sat | Akron | 17 | @ | Buffalo | 10 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 2 | Sep 18, 1999 | Sat | Marshall | 35 | Bowling Green State | 16 | ||
| 3 | Sep 18, 1999 | Sat | Miami (OH) | 35 | Eastern Michigan | 14 | ||
| 4 | Sep 18, 1999 | Sat | Toledo | 23 | @ | Ball State | 10 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 5 | Sep 25, 1999 | Sat | Eastern Michigan | 38 | Akron | 17 | ||
| 6 | Sep 25, 1999 | Sat | Kent State | 41 | Bowling Green State | 27 | ||
| 7 | Sep 25, 1999 | Sat | Miami (OH) | 24 | @ | Central Michigan | 16 | |
| 8 | Sep 25, 1999 | Sat | Ohio | 45 | Buffalo | 6 | ||
| 9 | Sep 25, 1999 | Sat | Western Michigan | 24 | @ | Northern Illinois | 21 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 10 | Oct 2, 1999 | Sat | Akron | 31 | @ | Ball State | 9 | |
| 11 | Oct 2, 1999 | Sat | Bowling Green State | 34 | Toledo | 23 | ||
| 12 | Oct 2, 1999 | Sat | (17) Marshall | 32 | @ | Miami (OH) | 14 | |
| 13 | Oct 2, 1999 | Sat | Northern Illinois | 45 | @ | Buffalo | 21 | |
| 14 | Oct 2, 1999 | Sat | Ohio | 31 | Kent State | 3 | ||
| 15 | Oct 2, 1999 | Sat | Western Michigan | 38 | Central Michigan | 16 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 16 | Oct 9, 1999 | Sat | Akron | 41 | Ohio | 28 | ||
| 17 | Oct 9, 1999 | Sat | Central Michigan | 38 | @ | Buffalo | 19 | |
| 18 | Oct 9, 1999 | Sat | Miami (OH) | 45 | @ | Bowling Green State | 31 | |
| 19 | Oct 9, 1999 | Sat | Northern Illinois | 37 | Ball State | 17 | ||
| 20 | Oct 9, 1999 | Sat | Toledo | 47 | Kent State | 7 | ||
| 21 | Oct 9, 1999 | Sat | Western Michigan | 40 | @ | Eastern Michigan | 37 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 22 | Oct 14, 1999 | Thu | (15) Marshall | 38 | Toledo | 13 | ||
| 23 | Oct 16, 1999 | Sat | Akron | 55 | Bowling Green State | 25 | ||
| 24 | Oct 16, 1999 | Sat | Eastern Michigan | 27 | Ohio | 26 | ||
| 25 | Oct 16, 1999 | Sat | Miami (OH) | 17 | @ | Kent State | 10 | |
| 26 | Oct 16, 1999 | Sat | Northern Illinois | 31 | @ | Central Michigan | 27 | |
| 27 | Oct 16, 1999 | Sat | Western Michigan | 45 | Buffalo | 17 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 28 | Oct 23, 1999 | Sat | Eastern Michigan | 20 | @ | Toledo | 13 | |
| 29 | Oct 23, 1999 | Sat | (15) Marshall | 59 | @ | Buffalo | 3 | |
| 30 | Oct 23, 1999 | Sat | Northern Illinois | 50 | Kent State | 7 | ||
| 31 | Oct 23, 1999 | Sat | Ohio | 17 | Bowling Green State | 14 | ||
| 32 | Oct 23, 1999 | Sat | Western Michigan | 28 | Ball State | 0 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 33 | Oct 30, 1999 | Sat | Bowling Green State | 31 | Central Michigan | 7 | ||
| 34 | Oct 30, 1999 | Sat | Kent State | 41 | Buffalo | 20 | ||
| 35 | Oct 30, 1999 | Sat | (13) Marshall | 41 | Northern Illinois | 9 | ||
| 36 | Oct 30, 1999 | Sat | Ohio | 37 | @ | Ball State | 25 | |
| 37 | Oct 30, 1999 | Sat | Western Michigan | 24 | @ | Akron | 10 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 38 | Nov 6, 1999 | Sat | Eastern Michigan | 31 | Ball State | 21 | ||
| 39 | Nov 6, 1999 | Sat | (13) Marshall | 28 | @ | Kent State | 16 | |
| 40 | Nov 6, 1999 | Sat | Miami (OH) | 32 | Akron | 23 | ||
| 41 | Nov 6, 1999 | Sat | Toledo | 32 | @ | Central Michigan | 13 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 42 | Nov 13, 1999 | Sat | Akron | 37 | Kent State | 34 | ||
| 43 | Nov 13, 1999 | Sat | Bowling Green State | 35 | Ball State | 14 | ||
| 44 | Nov 13, 1999 | Sat | Central Michigan | 29 | Eastern Michigan | 26 | ||
| 45 | Nov 13, 1999 | Sat | (12) Marshall | 31 | @ | Western Michigan | 17 | |
| 46 | Nov 13, 1999 | Sat | Ohio | 40 | Miami (OH) | 28 | ||
| 47 | Nov 13, 1999 | Sat | Toledo | 44 | Northern Illinois | 14 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 48 | Nov 20, 1999 | Sat | Central Michigan | 27 | @ | Ball State | 21 | |
| 49 | Nov 20, 1999 | Sat | Miami (OH) | 43 | Buffalo | 0 | ||
| 50 | Nov 20, 1999 | Sat | Northern Illinois | 30 | Eastern Michigan | 23 | ||
| 51 | Nov 20, 1999 | Sat | Toledo | 45 | Western Michigan | 21 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 52 | Nov 26, 1999 | Fri | (12) Marshall | 34 | Ohio | 3 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 53 | Dec 3, 1999 | Fri | (11) Marshall | 34 | Western Michigan | 30 | MAC Championship (Huntington, WV) |