Record: 162-121-0, .572 W-L% (2nd of 10) (Schedule and Results)
SRS: 3.09 (4th of 10) ▪ SOS: 0.83 (6th of 10)
Ranked in Preseason AP Poll: 6 (Florida State, Miami (FL), Notre Dame, Penn State, South Carolina and West Virginia)
Ranked in Final AP Poll: 5 (Florida State, Miami (FL), Notre Dame, Syracuse and West Virginia)
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
|---|---|---|---|---|---|---|---|---|
| 1 | Sep 3, 1988 | Sat | (6) Miami (FL) | 31 | (1) Florida State | 0 | ||
| 2 | Sep 3, 1988 | Sat | Northern Illinois | 7 | Akron | 6 | ||
| 3 | Sep 3, 1988 | Sat | Syracuse | 31 | Temple | 21 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 4 | Sep 10, 1988 | Sat | Boston College | 41 | Cincinnati | 7 | ||
| 5 | Sep 10, 1988 | Sat | (10) Florida State | 49 | Southern Mississippi | 13 | ||
| 6 | Sep 10, 1988 | Sat | Virginia Tech | 27 | East Carolina | 16 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 7 | Sep 17, 1988 | Sat | Louisville | 29 | Memphis | 18 | ||
| 8 | Sep 17, 1988 | Sat | (16) Penn State | 23 | Boston College | 20 | ||
| 9 | Sep 17, 1988 | Sat | (14) South Carolina | 17 | East Carolina | 0 | ||
| 10 | Sep 17, 1988 | Sat | Southern Mississippi | 35 | Virginia Tech | 13 | ||
| 11 | Sep 17, 1988 | Sat | Temple | 12 | @ | Navy | 7 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 12 | Sep 24, 1988 | Sat | Rutgers | 21 | @ | (15) Penn State | 16 | |
| 13 | Sep 24, 1988 | Sat | Southern Mississippi | 45 | @ | East Carolina | 42 | |
| 14 | Sep 24, 1988 | Sat | Syracuse | 35 | Virginia Tech | 0 | ||
| 15 | Sep 24, 1988 | Sat | Tulane | 20 | Memphis | 19 | ||
| 16 | Sep 24, 1988 | Sat | (11) West Virginia | 31 | @ | (16) Pittsburgh | 10 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 17 | Oct 1, 1988 | Sat | Boston College | 34 | Pittsburgh | 31 | ||
| 18 | Oct 1, 1988 | Sat | (6) Florida State | 48 | @ | Tulane | 28 | |
| 19 | Oct 1, 1988 | Sat | Louisiana-Lafayette | 48 | @ | East Carolina | 36 | |
| 20 | Oct 1, 1988 | Sat | Penn State | 45 | @ | Temple | 9 | Philadelphia, PA |
| 21 | Oct 1, 1988 | Sat | Rutgers | 38 | Cincinnati | 9 | ||
| 22 | Oct 1, 1988 | Sat | Southern Mississippi | 30 | Louisville | 23 | ||
| 23 | Oct 1, 1988 | Sat | (7) West Virginia | 22 | @ | Virginia Tech | 10 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 24 | Oct 8, 1988 | Sat | Louisiana Tech | 19 | Louisiana-Lafayette | 16 | ||
| 25 | Oct 8, 1988 | Sat | Louisville | 9 | Tulsa | 3 | ||
| 26 | Oct 8, 1988 | Sat | (5) Notre Dame | 30 | @ | Pittsburgh | 20 | |
| 27 | Oct 8, 1988 | Sat | Penn State | 35 | Cincinnati | 9 | ||
| 28 | Oct 8, 1988 | Sat | (8) South Carolina | 26 | @ | Virginia Tech | 24 | |
| 29 | Oct 8, 1988 | Sat | Southern Mississippi | 38 | @ | Tulane | 13 | |
| 30 | Oct 8, 1988 | Sat | Syracuse | 34 | Rutgers | 20 | ||
| 31 | Oct 8, 1988 | Sat | (7) West Virginia | 30 | @ | East Carolina | 10 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 32 | Oct 15, 1988 | Sat | (5) Florida State | 45 | East Carolina | 21 | ||
| 33 | Oct 15, 1988 | Sat | Louisiana-Lafayette | 45 | Northern Illinois | 0 | ||
| 34 | Oct 15, 1988 | Sat | (4) Notre Dame | 31 | (1) Miami (FL) | 30 | ||
| 35 | Oct 15, 1988 | Sat | Pittsburgh | 42 | Temple | 7 | ||
| 36 | Oct 15, 1988 | Sat | Rutgers | 17 | @ | Boston College | 6 | |
| 37 | Oct 15, 1988 | Sat | Syracuse | 24 | @ | Penn State | 10 | |
| 38 | Oct 15, 1988 | Sat | Virginia Tech | 41 | @ | Cincinnati | 14 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 39 | Oct 22, 1988 | Sat | Army | 34 | Rutgers | 24 | East Rutherford, NJ | |
| 40 | Oct 22, 1988 | Sat | (7) Florida State | 66 | Louisiana Tech | 3 | ||
| 41 | Oct 22, 1988 | Sat | Louisville | 38 | @ | Tulane | 35 | |
| 42 | Oct 22, 1988 | Sat | (4) Miami (FL) | 57 | Cincinnati | 3 | ||
| 43 | Oct 22, 1988 | Sat | Pittsburgh | 52 | Navy | 6 | ||
| 44 | Oct 22, 1988 | Sat | Southern Mississippi | 27 | @ | Louisiana-Lafayette | 14 | |
| 45 | Oct 22, 1988 | Sat | (19) Syracuse | 38 | @ | East Carolina | 14 | |
| 46 | Oct 22, 1988 | Sat | (6) West Virginia | 59 | Boston College | 19 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 47 | Oct 29, 1988 | Sat | Louisiana-Lafayette | 51 | @ | Tulane | 34 | |
| 48 | Oct 29, 1988 | Sat | Louisville | 21 | @ | Cincinnati | 6 | |
| 49 | Oct 29, 1988 | Sat | (4) Miami (FL) | 31 | @ | East Carolina | 7 | |
| 50 | Oct 29, 1988 | Sat | (2) Notre Dame | 22 | @ | Navy | 7 | Baltimore, MD |
| 51 | Oct 29, 1988 | Sat | Southern Mississippi | 34 | Memphis | 27 | ||
| 52 | Oct 29, 1988 | Sat | Temple | 35 | @ | Rutgers | 30 | |
| 53 | Oct 29, 1988 | Sat | (7) West Virginia | 51 | Penn State | 30 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 54 | Nov 5, 1988 | Sat | East Carolina | 34 | @ | Temple | 17 | |
| 55 | Nov 5, 1988 | Sat | (5) Florida State | 59 | @ | (15) South Carolina | 0 | |
| 56 | Nov 5, 1988 | Sat | Louisville | 13 | Virginia Tech | 3 | ||
| 57 | Nov 5, 1988 | Sat | Memphis | 20 | Louisiana-Lafayette | 3 | ||
| 58 | Nov 5, 1988 | Sat | (3) Miami (FL) | 34 | Tulsa | 3 | ||
| 59 | Nov 5, 1988 | Sat | Pittsburgh | 20 | Rutgers | 10 | ||
| 60 | Nov 5, 1988 | Sat | (16) Syracuse | 49 | Navy | 21 | ||
| 61 | Nov 5, 1988 | Sat | (4) West Virginia | 51 | @ | Cincinnati | 13 | Cincinnati, OH |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 62 | Nov 12, 1988 | Sat | (5) Florida State | 41 | Virginia Tech | 14 | ||
| 63 | Nov 12, 1988 | Sat | Memphis | 26 | Tulsa | 20 | ||
| 64 | Nov 12, 1988 | Sat | Pittsburgh | 14 | @ | Penn State | 7 | |
| 65 | Nov 12, 1988 | Sat | South Carolina | 19 | Navy | 8 | ||
| 66 | Nov 12, 1988 | Sat | Southern Mississippi | 26 | @ | Louisiana Tech | 19 | |
| 67 | Nov 12, 1988 | Sat | (15) Syracuse | 45 | @ | Boston College | 20 | |
| 68 | Nov 12, 1988 | Sat | Temple | 37 | @ | Akron | 17 | |
| 69 | Nov 12, 1988 | Sat | (4) West Virginia | 35 | @ | Rutgers | 25 | East Rutherford, NJ |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 70 | Nov 19, 1988 | Sat | Boston College | 38 | Army | 24 | Emerald Isle Classic (Dublin, Ireland) | |
| 71 | Nov 19, 1988 | Sat | East Carolina | 49 | @ | Cincinnati | 14 | |
| 72 | Nov 19, 1988 | Sat | (1) Notre Dame | 21 | Penn State | 3 | ||
| 73 | Nov 19, 1988 | Sat | Tulsa | 15 | Temple | 10 | ||
| 74 | Nov 19, 1988 | Sat | (4) West Virginia | 31 | (14) Syracuse | 9 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 75 | Nov 26, 1988 | Sat | Temple | 45 | Boston College | 28 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 76 | Dec 3, 1988 | Sat | Army | 20 | Navy | 15 | Philadelphia, PA | |
| 77 | Dec 3, 1988 | Sat | (18) Syracuse | 24 | Pittsburgh | 7 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 78 | Jan 2, 1989 | Mon | (1) Notre Dame | 34 | (3) West Virginia | 21 | Fiesta Bowl (Tempe, AZ) |