| Rank | Player | Yds | Year | School |
|---|---|---|---|---|
| 1. | Case Keenum* | 5829 | 2009 | Houston |
| 2. | Case Keenum* | 5666 | 2011 | Houston |
| 3. | Case Keenum* | 5241 | 2008 | Houston |
| 4. | Paul Smith* | 5184 | 2007 | Tulsa |
| 5. | Chase Clement* | 4812 | 2008 | Rice |
| 6. | David Johnson* | 4245 | 2008 | Tulsa |
| 7. | Rakeem Cato | 4232 | 2012 | Marshall |
| 8. | G.J. Kinne* | 4211 | 2010 | Tulsa |
| 9. | Shaun King* | 4149 | 1998 | Tulane |
| 10. | Dominique Davis* | 4108 | 2010 | East Carolina |
| 11. | Kyle Padron* | 4072 | 2010 | Southern Methodist |
| 12. | Chris Redman | 4009 | 1998 | Louisville |
| 13. | Kevin Kolb* | 3963 | 2006 | Houston |
| 14. | Chase Clement | 3912 | 2007 | Rice |
| 15. | Austin Davis* | 3848 | 2011 | Southern Mississippi |
| 16. | Joe Webb | 3726 | 2009 | Alabama-Birmingham |
| 17. | Justin Willis | 3643 | 2007 | Southern Methodist |
| 18. | Bernard Morris | 3637 | 2007 | Marshall |
| 19. | Austin Davis* | 3636 | 2008 | Southern Mississippi |
| 20. | Gino Guidugli* | 3570 | 2002 | Cincinnati |
| 21. | Austin Davis* | 3555 | 2010 | Southern Mississippi |
| 22. | Stefan Lefors* | 3550 | 2003 | Louisville |
| 23. | Chris Redman | 3537 | 1999 | Louisville |
| 24. | Jordan Palmer | 3509 | 2006 | Texas-El Paso |
| 25. | G.J. Kinne* | 3495 | 2011 | Tulsa |