Record*: 82-58, .586 W-L% (4th of 12) (Schedule and Results)
*W-L-T adjusted to 63-57 by NCAA.
SRS: 4.31 (5th of 12) ▪ SOS: 1.31 (5th of 12)
Conference Champion: Michigan State, Ohio State and Wisconsin
Ranked in Preseason AP Poll: 4 (Iowa, Ohio State, Penn State and Wisconsin)
Ranked in Final AP Poll: 3 (Michigan State, Ohio State and Wisconsin)
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oct 2, 2010 | Sat | (17) Iowa | 24 | (22) Penn State | 3 | ||
| 2 | Oct 2, 2010 | Sat | (19) Michigan | 42 | @ | Indiana | 35 | |
| 3 | Oct 2, 2010 | Sat | (24) Michigan State | 34 | (11) Wisconsin | 24 | ||
| 4 | Oct 2, 2010 | Sat | Northwestern | 29 | @ | Minnesota | 28 | |
| 5 | Oct 2, 2010 | Sat | (2) Ohio State | 24 | @ | Illinois | 13 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 6 | Oct 9, 2010 | Sat | Illinois | 33 | @ | Penn State | 13 | |
| 7 | Oct 9, 2010 | Sat | (17) Michigan State | 34 | @ | (18) Michigan | 17 | |
| 8 | Oct 9, 2010 | Sat | (2) Ohio State | 38 | Indiana | 10 | ||
| 9 | Oct 9, 2010 | Sat | Purdue | 20 | @ | Northwestern | 17 | |
| 10 | Oct 9, 2010 | Sat | (20) Wisconsin | 41 | Minnesota | 23 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 11 | Oct 16, 2010 | Sat | (15) Iowa | 38 | @ | Michigan | 28 | |
| 12 | Oct 16, 2010 | Sat | (13) Michigan State | 26 | Illinois | 6 | ||
| 13 | Oct 16, 2010 | Sat | Purdue | 28 | Minnesota | 17 | ||
| 14 | Oct 16, 2010 | Sat | (18) Wisconsin | 31 | (1) Ohio State | 18 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 15 | Oct 23, 2010 | Sat | Illinois | 43 | Indiana | 13 | ||
| 16 | Oct 23, 2010 | Sat | (8) Michigan State | 35 | @ | Northwestern | 27 | |
| 17 | Oct 23, 2010 | Sat | (11) Ohio State | 49 | Purdue | 0 | ||
| 18 | Oct 23, 2010 | Sat | Penn State | 33 | @ | Minnesota | 21 | |
| 19 | Oct 23, 2010 | Sat | (10) Wisconsin | 31 | @ | (13) Iowa | 30 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 20 | Oct 30, 2010 | Sat | Illinois | 44 | Purdue | 10 | ||
| 21 | Oct 30, 2010 | Sat | (18) Iowa | 37 | (5) Michigan State | 6 | ||
| 22 | Oct 30, 2010 | Sat | Northwestern | 20 | @ | Indiana | 17 | |
| 23 | Oct 30, 2010 | Sat | (10) Ohio State | 52 | @ | Minnesota | 10 | |
| 24 | Oct 30, 2010 | Sat | Penn State | 41 | Michigan | 31 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 25 | Nov 6, 2010 | Sat | (15) Iowa | 18 | @ | Indiana | 13 | |
| 26 | Nov 6, 2010 | Sat | Michigan | 67 | Illinois | 65 | ||
| 27 | Nov 6, 2010 | Sat | (16) Michigan State | 31 | Minnesota | 8 | ||
| 28 | Nov 6, 2010 | Sat | Penn State | 35 | Northwestern | 21 | ||
| 29 | Nov 6, 2010 | Sat | (7) Wisconsin | 34 | @ | Purdue | 13 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 30 | Nov 13, 2010 | Sat | Michigan | 27 | @ | Purdue | 16 | |
| 31 | Nov 13, 2010 | Sat | Minnesota | 38 | @ | Illinois | 34 | |
| 32 | Nov 13, 2010 | Sat | Northwestern | 21 | (13) Iowa | 17 | ||
| 33 | Nov 13, 2010 | Sat | (8) Ohio State | 38 | Penn State | 14 | ||
| 34 | Nov 13, 2010 | Sat | (6) Wisconsin | 83 | Indiana | 20 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 35 | Nov 20, 2010 | Sat | Illinois | 48 | @ | Northwestern | 27 | Chicago, IL |
| 36 | Nov 20, 2010 | Sat | (11) Michigan State | 35 | Purdue | 31 | ||
| 37 | Nov 20, 2010 | Sat | (8) Ohio State | 20 | @ | (21) Iowa | 17 | |
| 38 | Nov 20, 2010 | Sat | Penn State | 41 | Indiana | 24 | Landover, MD | |
| 39 | Nov 20, 2010 | Sat | (6) Wisconsin | 48 | @ | Michigan | 28 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 40 | Nov 27, 2010 | Sat | Indiana | 34 | @ | Purdue | 31 | |
| 41 | Nov 27, 2010 | Sat | (11) Michigan State | 28 | @ | Penn State | 22 | |
| 42 | Nov 27, 2010 | Sat | Minnesota | 27 | (24) Iowa | 24 | ||
| 43 | Nov 27, 2010 | Sat | (8) Ohio State | 37 | Michigan | 7 | ||
| 44 | Nov 27, 2010 | Sat | (5) Wisconsin | 70 | Northwestern | 23 |