Record*: 69-61, .531 W-L% (6th of 12) (Schedule and Results)
*W-L-T adjusted to 64-61 by NCAA.
SRS: 4.99 (5th of 12) ▪ SOS: 3.73 (3rd of 12)
Conference Champion: Michigan, Northwestern and Purdue
Ranked in Preseason AP Poll: 7 (Illinois, Michigan, Michigan State, Ohio State, Penn State, Purdue and Wisconsin)
Ranked in Final AP Poll: 3 (Michigan, Purdue and Wisconsin)
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
|---|---|---|---|---|---|---|---|---|
| 1 | Sep 23, 2000 | Sat | (10) Michigan | 35 | @ | (19) Illinois | 31 | |
| 2 | Sep 23, 2000 | Sat | Northwestern | 47 | @ | (7) Wisconsin | 44 | |
| 3 | Sep 23, 2000 | Sat | (14) Ohio State | 45 | Penn State | 6 | ||
| 4 | Sep 23, 2000 | Sat | (21) Purdue | 38 | Minnesota | 24 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 5 | Sep 30, 2000 | Sat | Indiana | 45 | Iowa | 33 | ||
| 6 | Sep 30, 2000 | Sat | (9) Michigan | 13 | (17) Wisconsin | 10 | ||
| 7 | Sep 30, 2000 | Sat | Minnesota | 44 | (24) Illinois | 10 | ||
| 8 | Sep 30, 2000 | Sat | Northwestern | 37 | @ | (18) Michigan State | 17 | |
| 9 | Sep 30, 2000 | Sat | Penn State | 22 | (22) Purdue | 20 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 10 | Oct 7, 2000 | Sat | Iowa | 21 | Michigan State | 16 | ||
| 11 | Oct 7, 2000 | Sat | Minnesota | 25 | Penn State | 16 | ||
| 12 | Oct 7, 2000 | Sat | (22) Northwestern | 52 | Indiana | 33 | ||
| 13 | Oct 7, 2000 | Sat | (8) Ohio State | 23 | @ | (24) Wisconsin | 7 | |
| 14 | Oct 7, 2000 | Sat | Purdue | 32 | (6) Michigan | 31 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 15 | Oct 14, 2000 | Sat | Illinois | 31 | Iowa | 0 | ||
| 16 | Oct 14, 2000 | Sat | (18) Michigan | 58 | Indiana | 0 | ||
| 17 | Oct 14, 2000 | Sat | Minnesota | 29 | @ | (6) Ohio State | 17 | |
| 18 | Oct 14, 2000 | Sat | (21) Purdue | 41 | @ | (17) Northwestern | 28 | |
| 19 | Oct 14, 2000 | Sat | Wisconsin | 17 | @ | Michigan State | 10 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 20 | Oct 21, 2000 | Sat | Indiana | 51 | (22) Minnesota | 43 | ||
| 21 | Oct 21, 2000 | Sat | (16) Michigan | 14 | Michigan State | 0 | ||
| 22 | Oct 21, 2000 | Sat | (14) Ohio State | 38 | @ | Iowa | 10 | |
| 23 | Oct 21, 2000 | Sat | Penn State | 39 | Illinois | 25 | ||
| 24 | Oct 21, 2000 | Sat | (17) Purdue | 30 | @ | Wisconsin | 24 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 25 | Oct 28, 2000 | Sat | Michigan State | 14 | Illinois | 10 | ||
| 26 | Oct 28, 2000 | Sat | (23) Northwestern | 41 | @ | Minnesota | 35 | |
| 27 | Oct 28, 2000 | Sat | Penn State | 27 | @ | Indiana | 24 | Indianapolis, IN |
| 28 | Oct 28, 2000 | Sat | (16) Purdue | 31 | (12) Ohio State | 27 | ||
| 29 | Oct 28, 2000 | Sat | Wisconsin | 13 | @ | Iowa | 7 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 30 | Nov 4, 2000 | Sat | Illinois | 42 | Indiana | 35 | ||
| 31 | Nov 4, 2000 | Sat | Iowa | 26 | @ | Penn State | 23 | |
| 32 | Nov 4, 2000 | Sat | (21) Northwestern | 54 | (12) Michigan | 51 | ||
| 33 | Nov 4, 2000 | Sat | (16) Ohio State | 27 | Michigan State | 13 | ||
| 34 | Nov 4, 2000 | Sat | Wisconsin | 41 | Minnesota | 20 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 35 | Nov 11, 2000 | Sat | Iowa | 27 | (12) Northwestern | 17 | ||
| 36 | Nov 11, 2000 | Sat | (20) Michigan | 33 | Penn State | 11 | ||
| 37 | Nov 11, 2000 | Sat | Michigan State | 30 | (9) Purdue | 10 | ||
| 38 | Nov 11, 2000 | Sat | (13) Ohio State | 24 | @ | Illinois | 21 | |
| 39 | Nov 11, 2000 | Sat | Wisconsin | 43 | @ | Indiana | 22 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 40 | Nov 18, 2000 | Sat | (19) Michigan | 38 | @ | (12) Ohio State | 26 | |
| 41 | Nov 18, 2000 | Sat | Minnesota | 27 | Iowa | 24 | ||
| 42 | Nov 18, 2000 | Sat | (23) Northwestern | 61 | Illinois | 23 | ||
| 43 | Nov 18, 2000 | Sat | Penn State | 42 | Michigan State | 23 | ||
| 44 | Nov 18, 2000 | Sat | (17) Purdue | 41 | Indiana | 13 |