| Rank | Player | Att | Year | School |
|---|---|---|---|---|
| 1. | Ray Rice* | 380 | 2007 | Rutgers |
| 2. | Donald Brown* | 367 | 2008 | Connecticut |
| 3. | Ray Rice* | 335 | 2006 | Rutgers |
| Avon Cobourne* | 335 | 2002 | West Virginia | |
| 5. | Jordan Todman* | 334 | 2010 | Connecticut |
| 6. | Dion Lewis* | 325 | 2009 | Pittsburgh |
| 7. | Derrick Knight* | 321 | 2003 | Boston College |
| 8. | Tanardo Sharps | 311 | 2002 | Temple |
| 9. | Lesean McCoy* | 308 | 2008 | Pittsburgh |
| Mike Cloud | 308 | 1998 | Boston College | |
| 11. | Amos Zereoue* | 283 | 1998 | West Virginia |
| 12. | Quincy Wilson* | 282 | 2003 | West Virginia |
| Willis McGahee* | 282 | 2002 | Miami (FL) | |
| 14. | Kevin Jones* | 281 | 2003 | Virginia Tech |
| Amos Zereoue* | 281 | 1997 | West Virginia | |
| 16. | Lesean McCoy | 276 | 2007 | Pittsburgh |
| 17. | Lyle McCombs | 275 | 2011 | Connecticut |
| 18. | Andre Hall* | 270 | 2005 | South Florida |
| 19. | Avon Cobourne | 267 | 2001 | West Virginia |
| 20. | William Green | 265 | 2001 | Boston College |
| 21. | Omari Walker | 261 | 1996 | Boston College |
| 22. | Derrick Knight* | 259 | 2002 | Boston College |
| 23. | Lee Suggs* | 257 | 2002 | Virginia Tech |
| 24. | Jawan Jamison* | 255 | 2012 | Rutgers |
| 25. | Walter Reyes | 253 | 2003 | Syracuse |