| Rank | Player | Yds | Year | School |
|---|---|---|---|---|
| 1. | Geno Smith* | 4385 | 2011 | West Virginia |
| 2. | Brian Brohm | 4024 | 2007 | Louisville |
| 3. | Ryan Nassib* | 3749 | 2012 | Syracuse |
| 4. | Teddy Bridgewater* | 3718 | 2012 | Louisville |
| 5. | Rod Rutherford* | 3679 | 2003 | Pittsburgh |
| 6. | Marc Bulger* | 3607 | 1998 | West Virginia |
| 7. | Mike Teel* | 3418 | 2008 | Rutgers |
| 8. | Glenn Foley | 3397 | 1993 | Boston College |
| 9. | Ken Dorsey* | 3369 | 2002 | Miami (FL) |
| 10. | Dan Orlovsky* | 3354 | 2004 | Connecticut |
| 11. | Tino Sunseri* | 3288 | 2012 | Pittsburgh |
| 12. | Alex Van Pelt | 3163 | 1992 | Pittsburgh |
| 13. | Ryan Hart | 3154 | 2004 | Rutgers |
| 14. | Mike Teel* | 3147 | 2007 | Rutgers |
| 15. | Ben Mauk* | 3121 | 2007 | Cincinnati |
| 16. | Gino Torretta | 3095 | 1991 | Miami (FL) |
| 17. | Tyler Palko* | 3067 | 2004 | Pittsburgh |
| 18. | Gino Torretta | 3060 | 1992 | Miami (FL) |
| 19. | Brian Brohm* | 3049 | 2006 | Louisville |
| 20. | Brian St. Pierre* | 2983 | 2002 | Boston College |
| 21. | Matt Grothe* | 2911 | 2008 | South Florida |
| 22. | Zach Collaros | 2902 | 2010 | Cincinnati |
| 23. | Brian Brohm* | 2883 | 2005 | Louisville |
| 24. | Tyler Palko | 2871 | 2006 | Pittsburgh |
| 25. | Alex Van Pelt | 2796 | 1991 | Pittsburgh |