Record: 37-41-4, .476 W-L% (9th of 12) (Schedule and Results)
SRS: 1.49 (6th of 12) ▪ SOS: 2.05 (6th of 12)
Conference Champion: Nebraska
Ranked in Preseason AP Poll: 1 (Nebraska)
Ranked in Final AP Poll: 2 (Missouri and Nebraska)
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
|---|---|---|---|---|---|---|---|---|
| 1 | Sep 25, 1965 | Sat | Missouri | 13 | @ | Oklahoma State | 0 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 2 | Oct 2, 1965 | Sat | Colorado | 36 | @ | Kansas State | 0 | |
| 3 | Oct 2, 1965 | Sat | (3) Nebraska | 44 | Iowa State | 0 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 4 | Oct 9, 1965 | Sat | Colorado | 34 | Oklahoma State | 11 | ||
| 5 | Oct 9, 1965 | Sat | Iowa State | 21 | @ | Kansas | 7 | |
| 6 | Oct 9, 1965 | Sat | Missouri | 28 | Kansas State | 6 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 7 | Oct 16, 1965 | Sat | Iowa State | 10 | Colorado | 10 | ||
| 8 | Oct 16, 1965 | Sat | (2) Nebraska | 41 | @ | Kansas State | 0 | |
| 9 | Oct 16, 1965 | Sat | Oklahoma | 21 | Kansas | 7 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 10 | Oct 23, 1965 | Sat | Kansas | 9 | Oklahoma State | 0 | ||
| 11 | Oct 23, 1965 | Sat | Missouri | 23 | @ | Iowa State | 7 | |
| 12 | Oct 23, 1965 | Sat | (3) Nebraska | 38 | Colorado | 13 | ||
| 13 | Oct 23, 1965 | Sat | Oklahoma | 27 | @ | Kansas State | 0 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 14 | Oct 30, 1965 | Sat | Colorado | 13 | @ | Oklahoma | 0 | |
| 15 | Oct 30, 1965 | Sat | Iowa State | 14 | Oklahoma State | 10 | ||
| 16 | Oct 30, 1965 | Sat | Kansas | 34 | Kansas State | 0 | ||
| 17 | Oct 30, 1965 | Sat | (3) Nebraska | 16 | @ | Missouri | 14 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 18 | Nov 6, 1965 | Sat | (9) Missouri | 20 | @ | Colorado | 7 | |
| 19 | Nov 6, 1965 | Sat | (3) Nebraska | 42 | Kansas | 6 | ||
| 20 | Nov 6, 1965 | Sat | Oklahoma | 24 | Iowa State | 20 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 21 | Nov 13, 1965 | Sat | Colorado | 21 | Kansas | 14 | ||
| 22 | Nov 13, 1965 | Sat | Iowa State | 38 | Kansas State | 6 | ||
| 23 | Nov 13, 1965 | Sat | (9) Missouri | 30 | Oklahoma | 0 | ||
| 24 | Nov 13, 1965 | Sat | (3) Nebraska | 21 | @ | Oklahoma State | 17 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 25 | Nov 20, 1965 | Sat | (8) Missouri | 44 | @ | Kansas | 20 | |
| 26 | Nov 20, 1965 | Sat | Oklahoma State | 31 | Kansas State | 7 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 27 | Nov 25, 1965 | Thu | (3) Nebraska | 21 | Oklahoma | 9 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 28 | Dec 4, 1965 | Sat | Oklahoma State | 17 | @ | Oklahoma | 16 |