Record: 75-54, .581 W-L% (3rd of 12) (Schedule and Results)
SRS: 8.37 (2nd of 12) ▪ SOS: 5.10 (2nd of 12)
Ranked in Preseason AP Poll: 6 (Kansas State, Oklahoma, Oklahoma State, Texas, Texas Christian and West Virginia)
Ranked in Final AP Poll: 3 (Kansas State, Oklahoma and Texas)
| Rushing | Receiving | Scrimmage | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rk | Player | School | Att | Yds | Avg | TD | Rec | Yds | Avg | TD | Plays | Yds | Avg | TD |
| 1 | Lache Seastrunk* | Baylor | 131 | 1012 | 7.7 | 7 | 9 | 107 | 11.9 | 1 | 140 | 1119 | 8.0 | 8 |
| 2 | Tony Pierson | Kansas | 117 | 760 | 6.5 | 4 | 21 | 291 | 13.9 | 2 | 138 | 1051 | 7.6 | 6 |
| 3 | Brennan Clay* | Oklahoma | 93 | 555 | 6.0 | 6 | 15 | 100 | 6.7 | 1 | 108 | 655 | 6.1 | 7 |
| 4 | Kenny Williams* | Texas Tech | 143 | 824 | 5.8 | 5 | 16 | 163 | 10.2 | 1 | 159 | 987 | 6.2 | 6 |
| 5 | Damien Williams* | Oklahoma | 176 | 946 | 5.4 | 11 | 34 | 320 | 9.4 | 1 | 210 | 1266 | 6.0 | 12 |
| 6 | Eric Stephens* | Texas Tech | 89 | 480 | 5.4 | 5 | 16 | 79 | 4.9 | 1 | 105 | 559 | 5.3 | 6 |
| 7 | Joseph Randle* | Oklahoma State | 274 | 1417 | 5.2 | 14 | 28 | 224 | 8.0 | 0 | 302 | 1641 | 5.4 | 14 |
| 8 | James White* | Iowa State | 99 | 505 | 5.1 | 2 | 20 | 137 | 6.9 | 0 | 119 | 642 | 5.4 | 2 |
| 9 | Taylor Cox | Kansas | 91 | 464 | 5.1 | 3 | 3 | 24 | 8.0 | 0 | 94 | 488 | 5.2 | 3 |
| 10 | John Hubert* | Kansas State | 189 | 947 | 5.0 | 15 | 18 | 98 | 5.4 | 1 | 207 | 1045 | 5.0 | 16 |
| 11 | Glasco Martin* | Baylor | 179 | 889 | 5.0 | 15 | 1 | 2 | 2.0 | 0 | 180 | 891 | 5.0 | 15 |
| 12 | Sadale Foster* | Texas Tech | 91 | 451 | 5.0 | 3 | 18 | 88 | 4.9 | 0 | 109 | 539 | 4.9 | 3 |
| 13 | Andrew Buie* | West Virginia | 179 | 851 | 4.8 | 7 | 28 | 318 | 11.4 | 0 | 207 | 1169 | 5.6 | 7 |
| 14 | Johnathan Gray* | Texas | 149 | 701 | 4.7 | 3 | 11 | 151 | 13.7 | 1 | 160 | 852 | 5.3 | 4 |
| 15 | B.J. Catalon* | Texas Christian | 123 | 582 | 4.7 | 0 | 23 | 152 | 6.6 | 1 | 146 | 734 | 5.0 | 1 |
| 16 | James Sims | Kansas | 218 | 1013 | 4.6 | 9 | 14 | 168 | 12.0 | 1 | 232 | 1181 | 5.1 | 10 |
| 17 | Joe Bergeron* | Texas | 127 | 567 | 4.5 | 16 | 9 | 84 | 9.3 | 0 | 136 | 651 | 4.8 | 16 |
| 18 | Collin Klein* | Kansas State | 207 | 920 | 4.4 | 23 | 0 | 0 | 0 | 207 | 920 | 4.4 | 23 | |
| 19 | Matthew Tucker* | Texas Christian | 118 | 515 | 4.4 | 6 | 10 | 69 | 6.9 | 1 | 128 | 584 | 4.6 | 7 |
| 20 | Shontrelle Johnson* | Iowa State | 115 | 504 | 4.4 | 2 | 14 | 115 | 8.2 | 1 | 129 | 619 | 4.8 | 3 |
| Rushing | Receiving | Scrimmage | ||||||||||||
| Rk | Player | School | Att | Yds | Avg | TD | Rec | Yds | Avg | TD | Plays | Yds | Avg | TD |
| 21 | Nick Florence* | Baylor | 139 | 568 | 4.1 | 10 | 0 | 0 | 0 | 139 | 568 | 4.1 | 10 | |
| 22 | Jarred Salubi* | Baylor | 116 | 464 | 4.0 | 3 | 8 | 44 | 5.5 | 0 | 124 | 508 | 4.1 | 3 |
| 23 | Trevone Boykin* | Texas Christian | 127 | 417 | 3.3 | 3 | 0 | 0 | 0 | 127 | 417 | 3.3 | 3 | |
| 24 | Steele Jantz* | Iowa State | 92 | 216 | 2.3 | 1 | 0 | 0 | 0 | 92 | 216 | 2.3 | 1 | |