Record: 85-57, .599 W-L% (1st of 12) (Schedule and Results)
SRS: 6.20 (4th of 12) ▪ SOS: 3.03 (4th of 12)
Division Champions: Colorado (North) and Texas (South)
Conference Champion: Texas (Won Championship Game 70-3)
Ranked in Preseason AP Poll: 4 (Oklahoma, Texas, Texas A&M and Texas Tech)
Ranked in Final AP Poll: 4 (Nebraska, Oklahoma, Texas and Texas Tech)
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oct 1, 2005 | Sat | Colorado | 34 | @ | Oklahoma State | 0 | |
| 2 | Oct 1, 2005 | Sat | Nebraska | 27 | (23) Iowa State | 20 | ||
| 3 | Oct 1, 2005 | Sat | Oklahoma | 43 | Kansas State | 21 | ||
| 4 | Oct 1, 2005 | Sat | (2) Texas | 51 | @ | Missouri | 20 | |
| 5 | Oct 1, 2005 | Sat | Texas A&M | 16 | Baylor | 13 | ||
| 6 | Oct 1, 2005 | Sat | (16) Texas Tech | 30 | Kansas | 17 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 7 | Oct 8, 2005 | Sat | Baylor | 23 | @ | Iowa State | 13 | |
| 8 | Oct 8, 2005 | Sat | Colorado | 41 | Texas A&M | 20 | ||
| 9 | Oct 8, 2005 | Sat | Kansas State | 12 | Kansas | 3 | ||
| 10 | Oct 8, 2005 | Sat | Missouri | 38 | @ | Oklahoma State | 31 | |
| 11 | Oct 8, 2005 | Sat | (2) Texas | 45 | Oklahoma | 12 | Dallas, TX | |
| 12 | Oct 8, 2005 | Sat | (15) Texas Tech | 34 | @ | Nebraska | 31 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 13 | Oct 15, 2005 | Sat | Missouri | 27 | Iowa State | 24 | ||
| 14 | Oct 15, 2005 | Sat | Nebraska | 23 | @ | Baylor | 14 | |
| 15 | Oct 15, 2005 | Sat | Oklahoma | 19 | @ | Kansas | 3 | Kansas City, MO |
| 16 | Oct 15, 2005 | Sat | (2) Texas | 42 | (24) Colorado | 17 | ||
| 17 | Oct 15, 2005 | Sat | Texas A&M | 62 | Oklahoma State | 23 | ||
| 18 | Oct 15, 2005 | Sat | (13) Texas Tech | 59 | Kansas State | 20 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 19 | Oct 22, 2005 | Sat | Colorado | 44 | Kansas | 13 | ||
| 20 | Oct 22, 2005 | Sat | Iowa State | 37 | Oklahoma State | 10 | ||
| 21 | Oct 22, 2005 | Sat | Missouri | 41 | Nebraska | 24 | ||
| 22 | Oct 22, 2005 | Sat | Oklahoma | 37 | Baylor | 30 | ||
| 23 | Oct 22, 2005 | Sat | (2) Texas | 52 | (10) Texas Tech | 17 | ||
| 24 | Oct 22, 2005 | Sat | Texas A&M | 30 | @ | Kansas State | 28 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 25 | Oct 29, 2005 | Sat | Colorado | 23 | @ | Kansas State | 20 | |
| 26 | Oct 29, 2005 | Sat | Iowa State | 42 | @ | Texas A&M | 14 | |
| 27 | Oct 29, 2005 | Sat | Kansas | 13 | Missouri | 3 | ||
| 28 | Oct 29, 2005 | Sat | Oklahoma | 31 | @ | Nebraska | 24 | |
| 29 | Oct 29, 2005 | Sat | (2) Texas | 47 | @ | Oklahoma State | 28 | |
| 30 | Oct 29, 2005 | Sat | (17) Texas Tech | 28 | @ | Baylor | 0 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 31 | Nov 5, 2005 | Sat | (25) Colorado | 41 | Missouri | 12 | ||
| 32 | Nov 5, 2005 | Sat | Iowa State | 45 | Kansas State | 17 | ||
| 33 | Nov 5, 2005 | Sat | Kansas | 40 | Nebraska | 15 | ||
| 34 | Nov 5, 2005 | Sat | (2) Texas | 62 | @ | Baylor | 0 | |
| 35 | Nov 5, 2005 | Sat | (16) Texas Tech | 56 | Texas A&M | 17 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 36 | Nov 12, 2005 | Sat | Iowa State | 30 | (22) Colorado | 16 | ||
| 37 | Nov 12, 2005 | Sat | Missouri | 31 | Baylor | 16 | ||
| 38 | Nov 12, 2005 | Sat | Nebraska | 27 | Kansas State | 25 | ||
| 39 | Nov 12, 2005 | Sat | Oklahoma | 36 | Texas A&M | 30 | ||
| 40 | Nov 12, 2005 | Sat | Oklahoma State | 24 | (13) Texas Tech | 17 | ||
| 41 | Nov 12, 2005 | Sat | (2) Texas | 66 | Kansas | 14 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 42 | Nov 19, 2005 | Sat | Baylor | 44 | Oklahoma State | 34 | ||
| 43 | Nov 19, 2005 | Sat | Kansas State | 36 | Missouri | 28 | ||
| 44 | Nov 19, 2005 | Sat | (21) Texas Tech | 23 | Oklahoma | 21 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 45 | Nov 25, 2005 | Fri | Nebraska | 30 | @ | Colorado | 3 | |
| 46 | Nov 25, 2005 | Fri | (2) Texas | 40 | @ | Texas A&M | 29 | |
| 47 | Nov 26, 2005 | Sat | Kansas | 24 | Iowa State | 21 | ||
| 48 | Nov 26, 2005 | Sat | Oklahoma | 42 | Oklahoma State | 14 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 49 | Dec 3, 2005 | Sat | (2) Texas | 70 | Colorado | 3 | Big 12 Championship (Houston, TX) |