Record: 42-37-0, .532 W-L% (3rd of 14) (Schedule and Results)
SRS: 6.25 (5th of 14) ▪ SOS: 5.70 (6th of 14)
Conference Champion: North Carolina
Ranked in Preseason AP Poll: 1 (North Carolina)
Ranked in Final AP Poll: 1 (North Carolina)
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
|---|---|---|---|---|---|---|---|---|
| 1 | Sep 20, 1980 | Sat | North Carolina State | 27 | @ | Virginia | 13 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 2 | Sep 27, 1980 | Sat | (14) North Carolina | 17 | (19) Maryland | 3 | ||
| 3 | Sep 27, 1980 | Sat | Virginia | 20 | @ | Duke | 17 | |
| 4 | Sep 27, 1980 | Sat | Wake Forest | 27 | @ | North Carolina State | 7 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 5 | Oct 11, 1980 | Sat | Clemson | 27 | @ | Virginia | 24 | |
| 6 | Oct 11, 1980 | Sat | (8) North Carolina | 27 | @ | Wake Forest | 9 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 7 | Oct 18, 1980 | Sat | Duke | 34 | @ | Clemson | 17 | |
| 8 | Oct 18, 1980 | Sat | Maryland | 11 | Wake Forest | 10 | ||
| 9 | Oct 18, 1980 | Sat | (8) North Carolina | 28 | North Carolina State | 8 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 10 | Oct 25, 1980 | Sat | Maryland | 17 | @ | Duke | 14 | |
| 11 | Oct 25, 1980 | Sat | North Carolina State | 24 | Clemson | 20 | ||
| 12 | Oct 25, 1980 | Sat | Virginia | 24 | @ | Wake Forest | 21 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 13 | Nov 1, 1980 | Sat | Clemson | 35 | @ | Wake Forest | 33 | |
| 14 | Nov 1, 1980 | Sat | Maryland | 24 | North Carolina State | 0 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 15 | Nov 8, 1980 | Sat | (14) North Carolina | 24 | @ | Clemson | 19 | |
| 16 | Nov 8, 1980 | Sat | Wake Forest | 27 | @ | Duke | 24 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 17 | Nov 15, 1980 | Sat | Maryland | 34 | Clemson | 7 | ||
| 18 | Nov 15, 1980 | Sat | (15) North Carolina | 26 | Virginia | 3 | ||
| 19 | Nov 15, 1980 | Sat | North Carolina State | 38 | Duke | 21 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 20 | Nov 22, 1980 | Sat | Maryland | 31 | @ | Virginia | 0 | |
| 21 | Nov 22, 1980 | Sat | (15) North Carolina | 44 | Duke | 21 |