Record: 36-45-0, .444 W-L% (11th of 12) (Schedule and Results)
SRS: -0.46 (6th of 12) ▪ SOS: 1.60 (6th of 12)
Conference Champion: Clemson
Ranked in Preseason AP Poll: 3 (Clemson, North Carolina and South Carolina)
Ranked in Final AP Poll: 1 (Clemson)
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
|---|---|---|---|---|---|---|---|---|
| 1 | Sep 19, 1959 | Sat | (18) Clemson | 20 | @ | (12) North Carolina | 18 | |
| 2 | Sep 19, 1959 | Sat | (14) South Carolina | 12 | Duke | 7 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 3 | Sep 26, 1959 | Sat | (5) Clemson | 47 | @ | Virginia | 0 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 4 | Oct 3, 1959 | Sat | North Carolina | 20 | North Carolina State | 12 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 5 | Oct 10, 1959 | Sat | Clemson | 23 | North Carolina State | 0 | ||
| 6 | Oct 10, 1959 | Sat | North Carolina | 19 | (11) South Carolina | 6 | ||
| 7 | Oct 10, 1959 | Sat | Wake Forest | 10 | @ | Maryland | 7 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 8 | Oct 17, 1959 | Sat | Maryland | 14 | North Carolina | 7 | ||
| 9 | Oct 17, 1959 | Sat | Wake Forest | 17 | @ | North Carolina State | 14 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 10 | Oct 22, 1959 | Thu | (17) Clemson | 27 | @ | South Carolina | 0 | |
| 11 | Oct 24, 1959 | Sat | Duke | 17 | @ | North Carolina State | 15 | |
| 12 | Oct 24, 1959 | Sat | North Carolina | 21 | @ | Wake Forest | 19 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 13 | Oct 31, 1959 | Sat | South Carolina | 22 | Maryland | 6 | ||
| 14 | Oct 31, 1959 | Sat | Wake Forest | 34 | Virginia | 12 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 15 | Nov 7, 1959 | Sat | (10) Clemson | 6 | Duke | 0 | ||
| 16 | Nov 7, 1959 | Sat | South Carolina | 32 | @ | Virginia | 20 | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 17 | Nov 14, 1959 | Sat | Duke | 27 | Wake Forest | 15 | ||
| 18 | Nov 14, 1959 | Sat | Maryland | 28 | @ | (11) Clemson | 25 | |
| 19 | Nov 14, 1959 | Sat | North Carolina | 41 | Virginia | 0 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 20 | Nov 21, 1959 | Sat | (19) Clemson | 33 | Wake Forest | 31 | ||
| 21 | Nov 21, 1959 | Sat | Maryland | 55 | Virginia | 12 | ||
| 22 | Nov 21, 1959 | Sat | South Carolina | 12 | North Carolina State | 7 | ||
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 23 | Nov 26, 1959 | Thu | North Carolina | 50 | @ | Duke | 0 | |
| 24 | Nov 28, 1959 | Sat | Wake Forest | 43 | South Carolina | 20 | Charlotte, NC | |
| Rk | Date | Day | Winner/Tie | Pts | Loser/Tie | Pts | Notes | |
| 25 | Dec 5, 1959 | Sat | Maryland | 33 | North Carolina State | 28 |