Overall: 17-13, .567 W-L% (117th of 264)
Conference: 6-8, 5th in ACC (Schedule and Results)
Coach: Mike Krzyzewski (17-13)
PS/G: 69.9 (136th of 264) ▪ PA/G: 66.9 (81st of 264)
SRS: 10.17 (35th of 264) ▪ SOS: 7.11 (24th of 264)
| G | Date | Type | Opponent | Conf | Tm | Opp | OT | W | L | Streak | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sat, Nov 29, 1980 | REG | Stetson | Ind | W | 67 | 49 | 1 | 0 | W 1 | ||
| 2 | Tue, Dec 2, 1980 | REG | @ | South Florida | Sun Belt | W | 83 | 72 | 2 | 0 | W 2 | |
| 3 | Fri, Dec 5, 1980 | REG | N | North Carolina | ACC | L | 76 | 78 | 2 | 1 | L 1 | |
| 4 | Sat, Dec 6, 1980 | REG | N | North Carolina State | ACC | L | 60 | 74 | 2 | 2 | L 2 | |
| 5 | Tue, Dec 9, 1980 | REG | @ | Vanderbilt | SEC | W | 72 | 69 | OT | 3 | 2 | W 1 |
| 6 | Fri, Dec 12, 1980 | REG | Virginia | ACC | L | 79 | 91 | 3 | 3 | L 1 | ||
| 7 | Fri, Dec 19, 1980 | REG | Brown | Ivy | W | 91 | 60 | 4 | 3 | W 1 | ||
| 8 | Sat, Dec 20, 1980 | REG | Detroit Mercy | MW City | W | 111 | 71 | 5 | 3 | W 2 | ||
| 9 | Mon, Dec 22, 1980 | REG | Pennsylvania | Ivy | W | 88 | 82 | 6 | 3 | W 3 | ||
| 10 | Sun, Dec 28, 1980 | REG | N | New Orleans | Ind | W | 77 | 63 | 7 | 3 | W 4 | |
| 11 | Mon, Dec 29, 1980 | REG | N | Tennessee | SEC | L | 69 | 90 | 7 | 4 | L 1 | |
| 12 | Sat, Jan 10, 1981 | REG | @ | Maryland | ACC | L | 79 | 94 | 7 | 5 | L 2 | |
| 13 | Wed, Jan 14, 1981 | REG | Wake Forest | ACC | L | 73 | 76 | 7 | 6 | L 3 | ||
| 14 | Sat, Jan 17, 1981 | REG | @ | North Carolina | ACC | L | 65 | 80 | 7 | 7 | L 4 | |
| 15 | Mon, Jan 19, 1981 | REG | George Mason | ECACS | W | 60 | 51 | 8 | 7 | W 1 | ||
| 16 | Wed, Jan 21, 1981 | REG | @ | North Carolina State | ACC | W | 56 | 47 | 9 | 7 | W 2 | |
| 17 | Sat, Jan 24, 1981 | REG | Clemson | ACC | W | 75 | 57 | 10 | 7 | W 3 | ||
| 18 | Tue, Jan 27, 1981 | REG | @ | Rutgers | EAA | W | 53 | 51 | 11 | 7 | W 4 | |
| 19 | Sat, Jan 31, 1981 | REG | @ | Virginia | ACC | L | 47 | 68 | 11 | 8 | L 1 | |
| 20 | Wed, Feb 4, 1981 | REG | @ | Georgia Tech | ACC | W | 82 | 68 | 12 | 8 | W 1 | |
| 21 | Sat, Feb 7, 1981 | REG | Maryland | ACC | W | 55 | 54 | 13 | 8 | W 2 | ||
| 22 | Sat, Feb 14, 1981 | REG | @ | Wake Forest | ACC | L | 52 | 58 | 13 | 9 | L 1 | |
| 23 | Thu, Feb 19, 1981 | REG | North Carolina State | ACC | L | 51 | 52 | 13 | 10 | L 2 | ||
| 24 | Sat, Feb 21, 1981 | REG | Georgia Tech | ACC | W | 83 | 56 | 14 | 10 | W 1 | ||
| 25 | Wed, Feb 25, 1981 | REG | @ | Clemson | ACC | L | 52 | 54 | OT | 14 | 11 | L 1 |
| 26 | Sat, Feb 28, 1981 | REG | North Carolina | ACC | W | 66 | 65 | OT | 15 | 11 | W 1 | |
| G | Date | Type | Opponent | Conf | Tm | Opp | OT | W | L | Streak | ||
| 27 | Thu, Mar 5, 1981 | CTOURN | N | Maryland | ACC | L | 53 | 56 | 15 | 12 | L 1 | |
| G | Date | Type | Opponent | Conf | Tm | Opp | OT | W | L | Streak | ||
| 28 | Thu, Mar 12, 1981 | NIT | North Carolina A&T | MEAC | W | 79 | 69 | 16 | 12 | W 1 | ||
| 29 | Mon, Mar 16, 1981 | NIT | Alabama | SEC | W | 75 | 70 | 17 | 12 | W 2 | ||
| 30 | Fri, Mar 20, 1981 | NIT | @ | Purdue | Big Ten | L | 69 | 81 | 17 | 13 | L 1 |